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Titolo:
PHAGE DISPLAY - STRUCTURE, ASSEMBLY AND ENGINEERING OF FILAMENTOUS BACTERIOPHAGE-M13
Autore:
MAKOWSKI L;
Indirizzi:
FLORIDA STATE UNIV,INST MOLEC BIOPHYS TALLAHASSEE FL 32306
Titolo Testata:
Current opinion in structural biology
fascicolo: 2, volume: 4, anno: 1994,
pagine: 225 - 230
SICI:
0959-440X(1994)4:2<225:PD-SAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE LIGANDS; COAT PROTEIN; SURFACE; LIBRARIES; ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
L. Makowski, "PHAGE DISPLAY - STRUCTURE, ASSEMBLY AND ENGINEERING OF FILAMENTOUS BACTERIOPHAGE-M13", Current opinion in structural biology, 4(2), 1994, pp. 225-230

Abstract

The filamentous bacteriophage M13 can be used to display foreign peptides and proteins, allowing the construction of therapeutic, diagnostic and technological tools of broad utility. Foreign peptides or proteins have been inserted at or near the amino termini of the viral structural proteins gp3 and gp8. Both of these sites appear to have intrinsic limitations that need to be better understood for the technology to reach its full potential. Recent analyses of the normal functions of these proteins provide a basis for understanding these limitations and may allow the identification of other potential sites for insertions. Conversely, detailed analysis of the nature of viable and lethal insertions is providing information about the structure and assembly of thephage not obtainable by other means.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:26:36