Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RESPIRATORY AFLATOXICOSIS - SUPPRESSION OF PULMONARY AND SYSTEMIC HOST DEFENSES IN RATS AND MICE
Autore:
JAKAB GJ; HMIELESKI RR; ZARBA A; HEMENWAY DR; GROOPMAN JD;
Indirizzi:
JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI BALTIMORE MD 21205 UNIV VERMONT,DEPT CIVIL & ENVIRONM ENGN BURLINGTON VT 05405
Titolo Testata:
Toxicology and applied pharmacology
fascicolo: 2, volume: 125, anno: 1994,
pagine: 198 - 205
SICI:
0041-008X(1994)125:2<198:RA-SOP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIGS; RETICULOENDOTHELIAL SYSTEM; COMPLEMENT ACTIVITY; AEROSOL INHALATION; CONTAMINATED CORN; IMMUNE FUNCTION; MYCO-TOXINS; AFLATOXIN-B1; EXPOSURE; CHICKENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Jakab et al., "RESPIRATORY AFLATOXICOSIS - SUPPRESSION OF PULMONARY AND SYSTEMIC HOST DEFENSES IN RATS AND MICE", Toxicology and applied pharmacology, 125(2), 1994, pp. 198-205

Abstract

Dietary aflatoxin B-1 (AFB(1)) exposure impairs innate and acquired host defenses resulting in increased susceptibility to infections in domesticated animals. Experimental studies have confirmed this observation by demonstrating the immunosuppressive effects of AFB(1) ingestion. In addition to being present in dietary components, AFB(1) is also found in significant amounts in respirable particles of grain dust. To determine the effect of respiratory tract exposure to AFB(1) on host defenses, rats and mice were exposed either by aerosol inhalation or intratracheal instillation to AFB(1). Nose-only inhalation exposure of rats to AFB(1) aerosols suppressed alveolar macrophage (AM) phagocytosisat an estimated dose of 16.8 mu g/kg with the effect persisting for approximately 2 weeks. To determine whether another mode of respiratorytract exposure, intratracheal instillation, reflected inhalation exposure, animals were treated with increasing concentrations of AFB(1) which also suppressed AM phagocytosis in a dose-related manner albeit atdoses at least an order of magnitude more than that obtained by aerosol inhalation. Intratracheal administration of AFB(1) also suppressed the release of tumor necrosis factor-alpha from AMs and impaired systemic innate and acquired immune defenses as shown, respectively, by suppression of peritoneal macrophage phagocytosis and the primary splenicantibody response. These findings demonstrate that experimental respiratory tract exposure to AFB(1) suppresses pulmonary and systemic hostdefenses and indicates that inhalation exposure to AFB(1) is an occupational hazard where exposure to AFB(1)-laden dust is common. (C) 1994Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:37:39