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Titolo:
DEATH EFFECTOR DOMAIN-CONTAINING HERPESVIRUS AND POXVIRUS PROTEINS INHIBIT BOTH FAS-INDUCED AND TNFR1-INDUCED APOPTOSIS
Autore:
BERTIN J; ARMSTRONG RC; OTTILIE S; MARTIN DA; WANG Y; BANKS S; WANG GH; SENKEVICH TG; ALNEMRI ES; MOSS B; LENARDO MJ; TOMASELLI KJ; COHEN JI;
Indirizzi:
NIAID,CLIN INVEST LAB,NIH,BLDG 10 BETHESDA MD 20892 NIAID,CLIN INVEST LAB,NIH BETHESDA MD 20892 NIAID,IMMUNOL LAB,NIH BETHESDA MD 20892 NIAID,VIRAL DIS LAB,NIH BETHESDA MD 20892 IUDN PHARMACEUT INC LA JOLLA CA 92037 THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,CTR APOPTOSIS RES PHILADELPHIA PA 19107 THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,KIMMEL CANC INST PHILADELPHIA PA 19107
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 4, volume: 94, anno: 1997,
pagine: 1172 - 1176
SICI:
0027-8424(1997)94:4<1172:DEDHAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; BACULOVIRUS P35 PROTEIN; EQUINE HERPESVIRUS-2; VIRUS-REPLICATION; CELLS; CRMA; CYTOTOXICITY; INTERACTS; SEQUENCE; RECEPTOR;
Keywords:
FADD; CASPASE; TUMOR NECROSIS FACTOR; MOLLUSCUM CONTAGIOSUM VIRUS; EQUINE HERPESVIRUS TYPE 2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J. Bertin et al., "DEATH EFFECTOR DOMAIN-CONTAINING HERPESVIRUS AND POXVIRUS PROTEINS INHIBIT BOTH FAS-INDUCED AND TNFR1-INDUCED APOPTOSIS", Proceedings of the National Academy of Sciences of the United Statesof America, 94(4), 1997, pp. 1172-1176

Abstract

To identify novel antiapoptotic proteins encoded by DNA viruses, we searched viral genomes for proteins that might interfere with Fas and TNFR1 apoptotic signaling pathways. We report here that equine herpesvirus type 2 E8 protein and molluscum contagiosum virus MC159 protein both show sequence similarity to the death effector domains (DEDs) of the Fas/TNFR1 signaling components FADD and caspase-8. Yeast two-hybrid analysis revealed that E8 protein interacted with the caspase-8 prodomain whereas MC159 protein interacted with FADD, Furthermore, expression of either E8 protein or MC159 protein protected cells from Fas-and TNFR1-induced apoptosis indicating that certain herpesviruses and poxviruses use DED-mediated interactions to interfere with apoptotic signaling pathways, These findings identify a novel control point exploited by viruses to regulate Fas- and TNFR1-mediated apoptosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:52:20