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Titolo:
IMMUNOHISTOCHEMICAL DETERMINATION OF ESTROGEN AND PROGESTERONE RECEPTORS AND DNA FLOW-CYTOMETRY IN ENDOMETRIAL CANCER
Autore:
HEINONEN PK; ISOLA J; KUOPPALA T;
Indirizzi:
UNIV TAMPERE,DEPT CLIN SCI,BOX 607 SF-33101 TAMPERE FINLAND UNIV TAMPERE,DEPT BIOMED SCI TAMPERE FINLAND UNIV HOSP TAMPERE,DEPT OBSTET & GYNECOL TAMPERE FINLAND
Titolo Testata:
International journal of gynecological cancer
fascicolo: 3, volume: 4, anno: 1994,
pagine: 169 - 173
SICI:
1048-891X(1994)4:3<169:IDOEAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC VALUE; BREAST-CARCINOMA; S-PHASE; PLOIDY; FEATURES;
Keywords:
ENDOMETRIAL CARCINOMA; ESTROGEN RECEPTOR; FLOW CYTOMETRY; PROGESTERONE RECEPTOR; S-PHASE FRACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P.K. Heinonen et al., "IMMUNOHISTOCHEMICAL DETERMINATION OF ESTROGEN AND PROGESTERONE RECEPTORS AND DNA FLOW-CYTOMETRY IN ENDOMETRIAL CANCER", International journal of gynecological cancer, 4(3), 1994, pp. 169-173

Abstract

Estrogen and progesterone receptor contents (ER, PR) were assessed byan immunohistochemical method and DNA ploidy and S-phase by flow cytometry in frozen endometrial cancer tissue sections from 39 cases. Comparison of the immunohistochemical and cytosol assays showed 81% and 84% concordance in ER and PR contents, respectively. An aneuploid DNA pattern was identified in 30% and a high S-phase fraction was found in 33% of 36 specimens studied. Negative ER status was associated with aneuploid and high S-phase fraction. A similar association was found between PR status and high S-phase fraction. Combined analysis of immunohistochemical receptor status and DNA flow cytometry in the same sample makes it possible to identify two strong predictive factors in endometrial adenocarcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:14:18