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Titolo:
DIMINISHED CARDIAC VAGAL TONE IN SCHIZOPHRENIA - ASSOCIATIONS TO BRAIN LATERALITY AND AGE-OF-ONSET
Autore:
MALASPINA D; BRUDER G; DALACK GW; STORER S; VANKAMMEN M; AMADOR X; GLASSMAN A; GORMAN J;
Indirizzi:
NEW YORK STATE PSYCHIAT INST & HOSP,722 W 168TH ST,BOX 2 NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DEPT PSYCHIAT NEW YORK NY 10032 ANN ARBOR VAMC ANN ARBOR MI 00000 UNIV MICHIGAN,DEPT PSYCHIAT ANN ARBOR MI 48109
Titolo Testata:
Biological psychiatry
fascicolo: 5, volume: 41, anno: 1997,
pagine: 612 - 617
SICI:
0006-3223(1997)41:5<612:DCVTIS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE-VARIABILITY; SKIN-CONDUCTANCE; PERCEPTUAL ASYMMETRY; CEREBRAL LATERALITY; ORIENTING RESPONSE; PSYCHOPATHOLOGY; DYSFUNCTION; DEPRESSION; DISORDER; WORDS;
Keywords:
SCHIZOPHRENIA; CARDIAC; HRV; LATERALITY; ANS; AGE OF ONSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D. Malaspina et al., "DIMINISHED CARDIAC VAGAL TONE IN SCHIZOPHRENIA - ASSOCIATIONS TO BRAIN LATERALITY AND AGE-OF-ONSET", Biological psychiatry, 41(5), 1997, pp. 612-617

Abstract

We measured high;frequency (rapid) heart rate variability (HRV) from 24-hour Holter electrocardiograms to index cardiovagal tone in 23 patients with DSM-III-R schizophrenia or schizoaffective disorder, High-frequency HRV, quantitated by measuring the percent of successive normalinterbeat intervals greater than 50 msec (PNN50), demonstrated a bimodal distribution: II of 23 patients had a PNN50 of greater than or equal to 8.0 (mean value = 17.7 +/- 11,0), and 12 had a PNN50 of less than or equal to 4.0 (mean value = 1.8 +/- 1.0); no subject had a PNN50 value between 4.0 and 8.0. All 12 low cardiovagal tone patients (versusonly 6/11 of the other patients) had a schizophrenia (nor schizoaffective) diagnosis (p = .013). PNN50 was not associated with present age,gender, smoking, Ie scores, or symptomatology, but patients with lower cardiovagal tone did have a significantly later age of onset (20.5 +/- 5.3 vs. 14.8 +/- 2.8 years: p = .005). PNN50 subgroups also differed on dichotic listening measures of brain laterality, The low group failed to show left ear (right hemisphere) advantage for complex tones seen in the other patients and normal adults, They also showed larger right ear (left hemisphere) advantage for dichotic words than the otherpatients, This evidence of relative right hemisphere disadvantage in patients with low cardiovagal tone is consistent with findings linkingautonomic nervous system and right hemisphere function. These findings also support the existence of subgroups of schizophrenia patients differing in autonomic activity, brain laterality, and clinical features. (C) 1997 Society of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 15:22:30