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Titolo:
ESTROGEN INDUCES EARLY AND TIMED ACTIVATION OF CYCLIN-DEPENDENT KINASE-4, KINASE-5, AND KINASE-6 AND INCREASES CYCLIN MESSENGER-RIBONUCLEIC-ACID EXPRESSION IN RAT UTERUS
Autore:
ALTUCCI L; ADDEO R; CICATIELLO L; GERMANO D; PACILIO C; BATTISTA T; CANCEMI M; PETRIZZI VB; BRESCIANI F; WEISZ A;
Indirizzi:
UNIV NAPLES 2,FAC MED & CHIRURG,IST PATOL GEN & ONCOL,LARGHETTO S ANIELLO CAPONAPOLI 2 I-80138 NAPLES ITALY UNIV NAPLES 2,FAC MED & CHIRURG,IST PATOL GEN & ONCOL I-80138 NAPLES ITALY
Titolo Testata:
Endocrinology
fascicolo: 3, volume: 138, anno: 1997,
pagine: 978 - 984
SICI:
0013-7227(1997)138:3<978:EIEATA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; C-FOS; MITOGENIC STIMULATION; UTERINE CELLS; RECEPTOR; PROTOONCOGENES; INHIBITORS; PROTEINS; JUN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
L. Altucci et al., "ESTROGEN INDUCES EARLY AND TIMED ACTIVATION OF CYCLIN-DEPENDENT KINASE-4, KINASE-5, AND KINASE-6 AND INCREASES CYCLIN MESSENGER-RIBONUCLEIC-ACID EXPRESSION IN RAT UTERUS", Endocrinology, 138(3), 1997, pp. 978-984

Abstract

Cyclin-dependent kinases (cdks) are serine-threonine protein kinases that play a key role in the regulation of the mitotic cycle, in transcription initiation, and in the control of specific metabolic path waysin eukaryotic cells, cdh activity is controlled via phosphode-phosphorylation of the catalytic subunits of these enzymes and their physicalassociation with cyclins and cdh inhibitors. In adult rats, estrogen stimulation results in massive proliferation of endometrial epithelialcells, accompanied by functional and structural modifications in all other tissue components of the uterus. We report here that administration of 17 beta-estradiol (E(2)) to adult ovariectomized rats induces within the first 25 h significant activation of cdk 4, 5, and 6, but not cdk 2, in the uterus, accompanied by increased expression of D-type (D1-3), A and E cyclin messenger RNAs (mRNAs). Furthermore, Expressionof the cdk inhibitor p27(Kip1), a key regulator of uterine functions,is induced by E(2) in this organ. Analysis of RNA extracted from E(2)-stimulated rat endometria shows early accumulation of D1 and D3, but not D2, cyclin mRNA, preceded by transient accumulation of c-fos mRNA. These results indicate an involvement of cdks and cyclins in estrogenactions in adult rat uterus and suggest that cyclins D1 and D3 are part of the molecular pathway that allows hormonal regulation of G(1) progression in endometrial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:59:49