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Titolo:
DEVELOPMENT OF A BIOARTIFICIAL LIVER USING ISOLATED HEPATOCYTES
Autore:
DIXIT V;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,LIVER BIOSUPPORT & HEPATITIS RES LAB,675 CIRCLE DR S LOS ANGELES CA 90024
Titolo Testata:
Artificial organs
fascicolo: 5, volume: 18, anno: 1994,
pagine: 371 - 384
SICI:
0160-564X(1994)18:5<371:DOABLU>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; EXPERIMENTAL HEPATIC-FAILURE; GUNN-RATS; ARTIFICIAL CELLS; HEPATOCELLULAR TRANSPLANTATION; MICROENCAPSULATED HEPATOCYTES; ASSIST DEVICE; SUPPORT; SURVIVAL; SPLEEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
V. Dixit, "DEVELOPMENT OF A BIOARTIFICIAL LIVER USING ISOLATED HEPATOCYTES", Artificial organs, 18(5), 1994, pp. 371-384

Abstract

Severe liver disease is very often life-threatening and dramatically diminishes quality of life. Liver support systems based on detoxification alone have been proved ineffective because they cannot correct biochemical disorders. An effective artificial liver support system should be capable of carrying out the liver's essential processes, such as synthetic and metabolic functions, detoxification, and excretion. It should be capable of sustaining patients with fulminant hepatic failure, preparing patients for liver transplantation when a donor liver is not readily available (i.e., bridge to transplantation), and improving the survival and quality of life for patients for whom transplantationis not a therapeutic option. Recent advances in cell biology, tissue culture techniques, and biotechnology have led the way for the potential use of isolated hepatocytes in treating an array of liver disorders. Isolated hepatocytes may be transplanted to replace liver-specific deficiencies or as an important element of an auxiliary hybrid, bioartificial extracorporeal liver support device, which are important therapeutic applications for treating severe liver disease. Recently, several hepatocyte-based liver support systems have been proposed. Although there is no current consensus on its eventual design configuration, the hollow fiber hepatocyte bioreactor shows the greatest promise. Furthermore, application of tissue engineering technology, based on cell-surface interaction studies proposed by our group and others, has enhanced interest in the development of highly efficient hybrid, bioartificial, liver support devices.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:24:52