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Titolo:
MOTOR AND MENTAL ASPECTS OF ACUTE EXTRAPYRAMIDAL SYNDROMES
Autore:
CASEY DE;
Indirizzi:
VET ADM MED CTR,PSYCHIAT SERV 116A,3710 SW US VET HOSP RD PORTLAND OR97207 OREGON HLTH SCI UNIV PORTLAND OR 97201 OREGON REG PRIMATE RES CTR BEAVERTON OR 97006
Titolo Testata:
Acta psychiatrica Scandinavica
, volume: 89, anno: 1994, supplemento:, 380
pagine: 14 - 20
SICI:
0001-690X(1994)89:<14:MAMAOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; NEUROLEPTIC-INDUCED AKATHISIA; TARDIVE-DYSKINESIA; INDUCED DYSTONIA; NONHUMAN-PRIMATES; DRUGS; HALOPERIDOL; D1-DOPAMINE; SCH-23390; CLOZAPINE;
Keywords:
SCHIZOPHRENIA; NEUROLEPTICS; DOPAMINE ANTAGONIST; EXTRAPYRAMIDAL SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Casey, "MOTOR AND MENTAL ASPECTS OF ACUTE EXTRAPYRAMIDAL SYNDROMES", Acta psychiatrica Scandinavica, 89, 1994, pp. 14-20

Abstract

Acute extrapyramidal syndromes (EPS) are one of the major limitationsto effective neuroleptic treatment. These disorders have both motor (objective) and mental (subjective) aspects, which must be considered in any evaluation and differential diagnosis of treatment-related side effects. The disorders of akathisia, acute dystonia and parkinsonism have unique features that are best understood in the context of a careful assessment of patient characteristics, drug factors and temporal aspects. Though acute EPS are commonly explained on the basis of dopamine D, receptor antagonism, data from several lines of study raise important questions about this hypothesis. The roles of receptor subtype specificity, brain region selectivity and ratios of different receptor subtype antagonism are discussed. New and novel antipsychotic drugs with low rates of EPS are important clinical advancements that will increase patients' ability to participate in therapy and rehabilitation andthus improve their quality of life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:27:35