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Titolo:
POSITRON EMISSION TOMOGRAPHY - A USEFUL D IAGNOSTIC-TEST IN CARDIOLOGY FOR THE ASSESSMENT OF MYOCARDIAL PERFUSION
Autore:
VOMDAHL J;
Indirizzi:
RHEIN WESTFAL TH AACHEN KLINIKUM,MED KLIN 1,PAUWELSSTR 30 D-52057 AACHEN GERMANY
Titolo Testata:
Herz
fascicolo: 1, volume: 22, anno: 1997,
pagine: 1 - 15
SICI:
0340-9937(1997)22:1<1:PET-AU>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
GER
Soggetto:
CORONARY-ARTERY DISEASE; REGIONAL BLOOD-FLOW; WALL-MOTION ABNORMALITIES; INTRAVENOUS N-13 AMMONIA; OPEN-CHESTED DOGS; COMPUTED-TOMOGRAPHY; NONINVASIVE QUANTIFICATION; VIABLE MYOCARDIUM; TL-201 SPECT; RB-82 PET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
117
Recensione:
Indirizzi per estratti:
Citazione:
J. Vomdahl, "POSITRON EMISSION TOMOGRAPHY - A USEFUL D IAGNOSTIC-TEST IN CARDIOLOGY FOR THE ASSESSMENT OF MYOCARDIAL PERFUSION", Herz, 22(1), 1997, pp. 1-15

Abstract

Positron emission tomography (PET) of the heart has gained widespreadscientific and clinical acceptance with regard to 2 indications: 1. the detetction of perfusion abnormalities by qualitative and semiquantitative analyses of perfusion images at rest and during physical or pharmacological stress using well validated perfusion tracers such as N-13 ammonia, Rb-82 rubidiumchloride, or O-15 labeled water, 2. Viabilityimaging of myocardial regions with reduced contractility by combiningperfusion measurements with substrate metabolism as assessed from F-18 deoxyglucose utilization. This overview summarizes the use of PET asa perfusion imaging method. With a sensitivity > 90% in combination with a high specificity, PET is today the best available nuclear imaging technique for the diagnosis of coronary artery disease (CAD). The short half-life of the perfusion tracers in combination with highly sophisticated hard- and software enables rapid PET studies with high patient throughput. The high diagnostic accuracy and the methological advantages as compared to conventional scintigraphy allows to use PET perfusion imaging for detection of subtle changes of the perfusion reserve for detection of CAD in high risk but asymptomatic patients as well asin patients with proven CAD undergoing various treatment forms such as risk factor reduction or coronary revascularization. In patients following orthotopic heart transplantation, evolving transplant vasculopathy can be detected at an early stage. Quantitative PET imaging at rest allows for detection of myocardial viability since cellular survivalis based on maintenance of a minimal perfusion and structural changescorrelate to the degree of perfusion reduction. Furthermore, quantitative assessment of the myocardial perfusion reserve detects the magnitude and competence of collaterals in regions with occluded epicardial arteries and thus, imaging of several coronary distribution territories in one noninvasive study. The cost of PET in combination with the cost of a cyclotron facility together with the demanding methological problems have limited the availability of PET to a few but sophisticatedcenters. Therefore, quantitative PET investigations have been performed predominantly for scientific purposes and the cost-effectiveness ofPET in the everyday clinical setting is not yet finally proven. However, the unique possibilities of PET to study noninvasively and quantitatively myocardial perfusion and metabolism as well as cardiac innervation and pharmacokinetics of cardiac drugs have established cardiac PET as a scientific tool of highest quality for the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:33:54