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Titolo:
COMPARISON BETWEEN VENOCONSTRICTOR EFFECTS OF SUMATRIPTAN AND ERGOTAMINE IN MIGRAINE PATIENTS
Autore:
PANCONESI A; ANSELMI B; CURRADI C; PERFETTO F; PILUSO A; FRANCHI G;
Indirizzi:
UNIV FLORENCE,INST INTERNAL MED 4,CTR HEADACHE,V PIERACCINI 18 I-50134 FLORENCE ITALY
Titolo Testata:
Headache
fascicolo: 4, volume: 34, anno: 1994,
pagine: 194 - 197
SICI:
0017-8748(1994)34:4<194:CBVEOS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIES; CORONARY-ARTERIES; 5-HYDROXYTRYPTAMINE; DIHYDROERGOTAMINE; HEADACHE; MECHANISMS; VEINS;
Keywords:
SUMATRIPTAN; ERGOTAMINE; 5-HYDROXYTRYPTAMINE; HAND VEIN; VENOCONSTRICTION; MIGRAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Panconesi et al., "COMPARISON BETWEEN VENOCONSTRICTOR EFFECTS OF SUMATRIPTAN AND ERGOTAMINE IN MIGRAINE PATIENTS", Headache, 34(4), 1994, pp. 194-197

Abstract

The vasoconstrictor activity of sumatriptan and ergotamine were compared by injecting these drugs in the hand vein of migraine subjects. Weused the ''venotest method'', which permits the evaluation of the venoconstrictor effect of small doses of drugs, acting locally in the hand vein. Sumatriptan injected at increasing doses in the hand vein provoked contraction only at high doses 1500 mug): venoconstriction lasted5-15 minutes and was similar in intensity and duration to that induced by 0.5-1 mug of 5-hydroxytryptamine (5-HT). Likewise, ergotamine induced contraction only at a dose of 50 mug: this venoconstrictor effectwas long lasting (at least 1 hour). Ergotamine-induced hand vein contraction, almost completely inhibited by ketanserin, seems mediated at least in part by 5-HT2 receptors, like the one induced by 5-HT and sumatriptan, already observed in a previous study. Clinical doses of ergotamine (0.25 mg intramuscular) and of sumatriptan (6 mg subcutaneous) do not provoke hand vein contraction for at least 1 hour: this could be due to a low activity of these drugs on the 5-HT2 vein receptors or a technique that is unsuitable to detect the vasoconstrictor effect ofdrugs given by the systemic route. The long lasting venoconstrictor effect of ergotamine may be due to a slow dissociation from receptor sites. The short vasoconstriction induced by sumatriptan could account for the recurrence of headache in many sumatriptan-treated migraine subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:38:26