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Titolo:
LOW-DENSITY-LIPOPROTEIN UPTAKE BY MACROPHAGES IN MULTIPLE-SCLEROSIS PLAQUES - IMPLICATIONS FOR PATHOGENESIS
Autore:
NEWCOMBE J; LI H; CUZNER ML;
Indirizzi:
INST NEUROL,MULTIPLE SCLEROSIS LAB,1 WAKEFIELD ST LONDON WC1N 1PJ ENGLAND
Titolo Testata:
Neuropathology and applied neurobiology
fascicolo: 2, volume: 20, anno: 1994,
pagine: 152 - 162
SICI:
0305-1846(1994)20:2<152:LUBMIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PROTEIN ADDUCTS; ATHEROSCLEROTIC LESIONS; OXIDATIVE MODIFICATION; WHITE MATTER;
Keywords:
MULTIPLE SCLEROSIS; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; DEMYELINATION; MACROPHAGES; BLOOD-BRAIN BARRIER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J. Newcombe et al., "LOW-DENSITY-LIPOPROTEIN UPTAKE BY MACROPHAGES IN MULTIPLE-SCLEROSIS PLAQUES - IMPLICATIONS FOR PATHOGENESIS", Neuropathology and applied neurobiology, 20(2), 1994, pp. 152-162

Abstract

Low density lipoprotein (LDL), the major carrier of plasma cholesterol, may enter the parenchyma of early multiple sclerosis (MS) lesions as a result of blood-brain barrier damage. We have used antibodies against LDL and epitopes found in LDL oxidized by two peroxidative end-products, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), to immunocytochemically stain MS plaques at different stages of pathology. NativeLDL, epitopes of MDA-LDL, peptides of myelin basic protein and neutral lipid oil red O (ORO) staining were found to be co-localized within foamy macrophages in early and actively demyelinating MS plaques. Thuscholesterol esters, which are seen as Maltese crosses under polarizedlight in a proportion of foamy macrophages, appear to be derived fromboth LDL and myelin. ORO-negative astrocytes were strongly stained with the antibodies against 4-HNE-LDL and MDA-LDL, suggesting uptake of oxidatively modified protein products alone. Our findings suggest thata large proportion of the plasma LDL which enters the parenchyma of MS plaques is oxidatively modified in the lesion. Lipid peroxidation and oxidized LDL uptake by activated microglia and infiltrating macrophages in the early stages of MS plaque development may play important roles in demyelination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:37:43