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Titolo:
THE EFFECT OF AN ANTILIPOLYTIC AGENT (ACIPIMOX) ON THE INSULIN-RESISTANCE OF LIPID AND GLUCOSE-METABOLISM IN HYPERTRIGLYCERIDEMIC PATIENTS
Autore:
SALORANTA C; GROOP L; EKSTRAND A; FRANSSILAKALLUNKI A; TASKINEN MR;
Indirizzi:
HELSINKI UNIV HOSP,DEPT MED 4,UNIONINKATU 38 SF-00170 HELSINKI FINLAND HELSINKI UNIV HOSP,DEPT MED 3 HELSINKI FINLAND
Titolo Testata:
Acta diabetologica
fascicolo: 1, volume: 31, anno: 1994,
pagine: 6 - 13
SICI:
0940-5429(1994)31:1<6:TEOAAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE FATTY-ACIDS; DEPENDENT DIABETES-MELLITUS; ENDOGENOUS HYPERTRIGLYCERIDEMIA; TRANSPORT KINETICS; PLASMA-GLUCOSE; OBESE SUBJECTS; TURNOVER; THERAPY; GLUCONEOGENESIS; TRIGLYCERIDES;
Keywords:
HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; ANTILIPOLYSIS; ACIPIMOX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
C. Saloranta et al., "THE EFFECT OF AN ANTILIPOLYTIC AGENT (ACIPIMOX) ON THE INSULIN-RESISTANCE OF LIPID AND GLUCOSE-METABOLISM IN HYPERTRIGLYCERIDEMIC PATIENTS", Acta diabetologica, 31(1), 1994, pp. 6-13

Abstract

Hypertriglyceridaemia is associated with insulin resistance of both lipid and glucose metabolism. It is not known whether the insulin resistance affects both glucose oxidation and glycogen formation. To study the oxidative and non-oxidative pathways of non-esterified fatty acids(NEFA) and glucose metabolism, eight male hypertriglyceridaemic subjects were studied during insulin infusion (75 and 340 pmol/m(2).min) incombination with indirect calorimetry and infusions of [3-H-3]glucoseand [1-C-14]palmitate before and after 4 weeks of treatment with the antilipolytic agent acipimox (250 mg three times daily). Compared witheight healthy subjects the hypertriglyceridaemic subjects were resistant to the antilipolytic effect of insulin, both in the basal state (P< 0.05) and during insulin infusion (P < 0.05). This was associated with impaired insulin-stimulated glucose uptake (P < 0.05), predominantly in the non-oxidative pathway (P < 0.05). Acipimox decreased basal NEFA concentrations (P < 0.01) and reduced lipid oxidation during low-dose insulin infusion (P < 0.05). Glucose uptake, predominantly glycogen formation, was stimulated by acipimox (P < 0.05). In conclusion, theinsulin resistance of glucose metabolism associated with hypertriglyceridaemia is largely due to a defect in non-oxidative glucose metabolism. Acipimox improves glucose metabolism both by affecting glucose oxidation (low-dose insulin) and non-oxidative glucose metabolism (high-dose insulin).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 14:57:45