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Titolo:
METABOLIC AND ANTIOXIDANT ENZYME-ACTIVITIES IN THE DIAPHRAGM - EFFECTS OF ACUTE EXERCISE
Autore:
LAWLER JM; POWERS SK; VANDIJK H; VISSER T; KORDUS MJ; JI LL;
Indirizzi:
TEXAS A&M UNIV,DEPT HLTH & KINESIOL,HUMAN PERFORMANCE LAB COLLEGE STNTX 77843 UNIV FLORIDA,CTR EXERCISE SCI,DEPT EXERCISE & SPORT SCI GAINESVILLE FL 32611 UNIV FLORIDA,CTR EXERCISE SCI,DEPT PHYSIOL GAINESVILLE FL 32611 UNIV ILLINOIS,DEPT KINESIOL URBANA IL 61801
Titolo Testata:
Respiration physiology
fascicolo: 2-3, volume: 96, anno: 1994,
pagine: 139 - 149
SICI:
0034-5687(1994)96:2-3<139:MAAEIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; EXHAUSTIVE EXERCISE; OXYGEN;
Keywords:
ENZYME, METABOLIC; EXERCISE; MAMMALS, RAT; MUSCLE, DIAPHRAGM; OXYGEN RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Lawler et al., "METABOLIC AND ANTIOXIDANT ENZYME-ACTIVITIES IN THE DIAPHRAGM - EFFECTS OF ACUTE EXERCISE", Respiration physiology, 96(2-3), 1994, pp. 139-149

Abstract

Disruption of cellular constituents including inhibition or ''downregulation'' of metabolic enzyme activity has been associated with free radical stress in locomotor muscle with acute, strenuous exercise. However, the effects of acute, strenuous exercise on important metabolic and antioxidant enzyme activity levels in the diaphragm are unknown. Twenty 4-month-old and twenty 24-month-old female Fischer-344 rats were divided at random into young exercised (YE; n = 10)/ old exercised (OE; n = 10); young control (YC; n = 10)/old control (OC; n = 10) groups. Animals in both young and old exercise groups ran on a treadmill (10%uphill grade) for 40 min at similar to 75% of age group V(O2)max. Immediately following the treadmill run, both exercise and control groupswere euthanized with sodium pentobarbital. Costal (COD) and crural diaphragm (CRD) were quickly removed and frozen in liquid nitrogen. Lipid peroxidation was significantly increased (P<0.05) in COD of YE vs. YC rats. Activity of the antioxidant enzyme glutathione peroxidase (GPX) was unaltered in the diaphragm by acute exercise (P>0.05) in both age groups. There was a significant increase in superoxide dismutase (SOD) activity with exercise (P<0.05). Post-hocs revealed SOD activity was similar to 20% greater (P = 0.066) in YE CRD only. Activities of themetabolic enzymes phosphofructokinase (PFK), succinate dehydrogenase (SDH), and citrate synthase (CS) were not affected by acute exercise in YE or OE. Strenuous exercise resulted in a small trend towards a decrease in 3-hydroxyacyl-CoA dehydrogenase (HADH) activity in YE COD (P = 0.115) and YE CRD (P = 0.082). We conclude that the employed bout ofexercise induces some free radical stress, while metabolic enzymes are protected, in the diaphragm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:22:24