Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HYPOXIC VASOCONSTRICTION IN RAT PULMONARY AND MESENTERIC-ARTERIES
Autore:
LEACH RM; ROBERTSON TP; TWORT CHC; WARD JPT;
Indirizzi:
UNITED MED & DENT SCH GUYS & ST THOMASS HOSP,DEPT MED,DIV MED LONDON SE1 7EH ENGLAN UNITED MED & DENT SCH GUYS & ST THOMASS HOSP,DEPT MED,DIV MED LONDON SE1 7EH ENGLAND
Titolo Testata:
The American journal of physiology
fascicolo: 3, volume: 266, anno: 1994,
parte:, 1
pagine: 120000223 - 120000231
SICI:
0002-9513(1994)266:3<120000223:HVIRPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; CONTRACTION; ANTAGONISTS; INHIBITION; SUBSTANCE; INVITRO; CELLS;
Keywords:
PULMONARY VASCULATURE; HYPOXIA; ENDOTHELIUM; ENDOTHELIUM-DERIVED CONSTRICTING FACTOR; RESISTANCE ARTERIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Leach et al., "HYPOXIC VASOCONSTRICTION IN RAT PULMONARY AND MESENTERIC-ARTERIES", The American journal of physiology, 266(3), 1994, pp. 120000223-120000231

Abstract

Hypoxic vasoconstriction was investigated in isolated pulmonary and mesenteric arteries of the rat. Experiments were performed on large (similar to 2 mm pulmonary, similar to 0.8 mm mesenteric) and small (100-350 mu m) arteries. Hypoxia [oxygen partial pressure (PO2) similar to 33 mmHg] elicited a biphasic response in arteries precontracted with prostaglandin F-2 alpha (10 mu M). A transient contraction reaching a peak within 2-3 min was observed in both large and small pulmonary and mesenteric arteries (phase 1). In pulmonary arteries, this was followed by a slowly developing contraction over 45 min (phase 2). In mesenteric arteries, there was no phase 2 but instead a profound relaxation. Mechanical disruption of the endothelium had no significant effect on phase 1 in preconstricted large pulmonary arteries but reduced phase 1in small arteries by 40%. Phase 2 was abolished in both large and small arteries. Inhibition of endothelium-derived relaxing factor synthesis or cyclooxygenase pathways had no effect on either phase. Verapamilsubstantially reduced phase 1 but abolished phase 2. In conclusion, we have found a clear biphasic response to hypoxia in pulmonary arteries of the rat, but, in contrast to some previous reports, phase 1 was only partially dependent on the endothelium, whereas phase 2 was entirely dependent on the endothelium. Small and large arteries had qualitatively similar responses. These results are consistent with the involvement of at least two mechanisms for hypoxic vasoconstriction, one of which may involve release of an as yet unidentified endothelium-derivedconstrictor factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:42:48