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Titolo:
LONG-TERM EFFECTS OF RADIATION FOR MEDULLOBLASTOMA ON INTELLECTUAL AND PHYSICAL DEVELOPMENT - A CASE-REPORT OF MONOZYGOTIC TWINS
Autore:
NISHIYAMA K; FUNAKOSHI S; IZUMOTO S; IKEDA T; OKU Y;
Indirizzi:
KINKI CENT HOSP,DEPT RADIOL,3-1 KURUMAZUKA ITAMI HYOGO 664 JAPAN KANSAI ROSAI HOSP,DEPT PEDIAT AMAGASAKI HYOGO JAPAN KANSAI ROSAI HOSP,DEPT NEUROSURG AMAGASAKI HYOGO JAPAN OSAKA UNIV,SCH MED,DEPT NEUROSURG OSAKA JAPAN
Titolo Testata:
Cancer
fascicolo: 9, volume: 73, anno: 1994,
pagine: 2450 - 2455
SICI:
0008-543X(1994)73:9<2450:LEORFM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOCYTIC-LEUKEMIA; CRANIAL IRRADIATION; CEREBELLAR MEDULLOBLASTOMA; ADJUVANT CHEMOTHERAPY; ENDOCRINE SEQUELAE; BRAIN-TUMORS; CHILDREN; CHILDHOOD; GROWTH; SURVIVAL;
Keywords:
MEDULLOBLASTOMA; RADIATION THERAPY; LONG-TERM EFFECT; PHYSICAL DEVELOPMENT; INTELLECTUAL DEVELOPMENT;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K. Nishiyama et al., "LONG-TERM EFFECTS OF RADIATION FOR MEDULLOBLASTOMA ON INTELLECTUAL AND PHYSICAL DEVELOPMENT - A CASE-REPORT OF MONOZYGOTIC TWINS", Cancer, 73(9), 1994, pp. 2450-2455

Abstract

Background. Recent advances in treatment have improved the prognosis for medulloblastoma. Although postoperative radiation of the central nervous system (CNS) is widely practiced, late radiation sequelae, especially in long-term survivors, pose a constant risk. Methods. To assess the long-term effects of CNS radiation, a monozygotic twin girl withmedulloblastoma was compared with her normal twin. Treatment includedtotal removal of the mass, postoperative chemotherapy, and CNS radiation with 47.8 Gy directed to the posterior fossa, 30.2 Gy to the cerebral hemispheres, and 20 Gy to the whole spine. Results. Not only the radiated patient's spine but also the unradiated upper and lower limbs were shorter than the control subject's. The patient's thyroid hormonelevel was within normal range; however, thyroid-stimulating hormone was higher than normal. The patient's intellectual ability deteriorated, and cognitive dysfunction has not improved as of 6 years after treatment. Conclusions. Treatment systems that do not cause late sequelae affecting physical and intellectual development should be pursued.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:29:10