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Titolo:
INTRASPINAL WILMS-TUMOR METASTASES
Autore:
COHN SL; HAMRE M; KLETZEL M; CHOU P; RADKOWSKI MA;
Indirizzi:
CHILDRENS MEM HOSP,DIV HEMATOL ONCOL,2300 CHILDRENS PLAZA CHICAGO IL 60614 NORTHWESTERN UNIV,MED CTR,DEPT PEDIAT CHICAGO IL 60611 NORTHWESTERN UNIV,MED CTR,DEPT PATHOL CHICAGO IL 60611 NORTHWESTERN UNIV,MED CTR,DEPT RADIOL CHICAGO IL 60611
Titolo Testata:
Cancer
fascicolo: 9, volume: 73, anno: 1994,
pagine: 2444 - 2449
SICI:
0008-543X(1994)73:9<2444:IWM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL-CORD COMPRESSION; PROGNOSIS; CHILDHOOD; CHILDREN;
Keywords:
WILMS TUMOR; INTRASPINAL METASTASIS; CORD COMPRESSION; MULTIMODALITY THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Cohn et al., "INTRASPINAL WILMS-TUMOR METASTASES", Cancer, 73(9), 1994, pp. 2444-2449

Abstract

Background. Intraspinal Wilms' tumor metastasis is rare, and is associated with a high mortality rate. Methods. The authors reviewed the clinical course of two patients with Wilms' tumor in whom extradural metastasis developed. In addition, a review of the literature and of patients entered in the National Wilms' Tumor Studies was performed to determine the clinical presentation, treatment, and outcome of other patients with Wilms' tumor with intraspinal metastases. Results. Both of the patients initially had abdominal pain without neurologic deficits. Despite therapy, paraplegia secondary to cord compression from recurrent epidural metastases developed in one patient, although a third remission has been achieved with further chemotherapy. The second patient remains in disease-free remission 25+ months after surgical resection of the extradural spinal tumor, adjuvant chemotherapy and radiation therapy, and autologous bone marrow transplantation. Review of the literature and of the patients entered in the National Wilms' Tumor Studiesrevealed an additional 27 patients with Wilms' tumor with this pattern of metastasis. Only four were disease-free at the time of this report. Conclusions. The authors' experience stresses the importance of early recognition and treatment of this complication of Wilms' tumor and demonstrates that intensive multimodality therapy can result in long-term disease-free remission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:36:39