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Titolo:
NERVE GROWTH-FACTOR (NGF) IN CEREBROSPINAL-FLUID (CSF) FROM PATIENTS WITH VARIOUS NEUROLOGICAL DISORDERS
Autore:
MASSARO AR; SORANZO C; BIGON E; BATTISTON S; MORANDI A; CARNEVALE A; CALLEGARO L;
Indirizzi:
UNIV SACRO CUORE,IST NEUROL,LARGO A GEMELLI 8 I-00168 ROME ITALY
Titolo Testata:
Italian journal of neurological sciences
fascicolo: 2, volume: 15, anno: 1994,
pagine: 105 - 108
SICI:
0392-0461(1994)15:2<105:NG(IC(>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1; SYSTEM;
Keywords:
NERVE GROWTH FACTOR (NGF); CEREBROSPINAL FLUID (CSF); NEUROLOGICAL DISEASES; MULTIPLE SCLEROSIS (MS); AMYOTROPHIC LATERAL SCLEROSIS (ALS);
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Massaro et al., "NERVE GROWTH-FACTOR (NGF) IN CEREBROSPINAL-FLUID (CSF) FROM PATIENTS WITH VARIOUS NEUROLOGICAL DISORDERS", Italian journal of neurological sciences, 15(2), 1994, pp. 105-108

Abstract

It has been recently shown that NGF is not only involved in the survival and development of sympathetic and neural crest-derived sensory neurons, but also in some mechanisms of the immune system. For this reason, we studied the content of NGF in CSF samples from patients with diseases in which neuroimmonological mechanisms seem to be involved (multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, chronic relapsing polyradiculoneuritis, Guillain-Barre syndrome, and tumors of the nervous system), as well as from a number of normal control subjects. We setup an ELISA aimed at the beta subunit of NGF, obtaining good validation tests and a detection limit of 28 pg betaNGF per ml. None of the samples was found to contain detectable levels of NGF and, when a concentration method for sample enrichment was used, only onepatient was NGF-positive. This suggests that NGF is probably not involved in the neuroimmunological mechanisms underlying some inflammatoryand degenerative diseases of the nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:49:44