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Titolo:
CHOLINE-ACETYLTRANSFERASE - CELEBRATING ITS 50TH YEAR
Autore:
WU DH; HERSH LB;
Indirizzi:
UNIV KENTUCKY,COLL MED,CHANDLER MED CTR,DEPT BIOCHEM,800 ROSE ST LEXINGTON KY 40536 UNIV KENTUCKY,COLL MED,CHANDLER MED CTR,DEPT BIOCHEM LEXINGTON KY 40536
Titolo Testata:
Journal of neurochemistry
fascicolo: 5, volume: 62, anno: 1994,
pagine: 1653 - 1663
SICI:
0022-3042(1994)62:5<1653:C-CI5Y>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERATURE-SENSITIVE MUTANTS; CENTRAL-NERVOUS-SYSTEM; MEMBRANE-BOUND FRACTIONS; MESSENGER-RNA; O-ACETYLTRANSFERASE; INSITU HYBRIDIZATION; RAT-BRAIN; DROSOPHILA-MELANOGASTER; GENE-EXPRESSION; GROWTH-FACTOR;
Keywords:
ACETYLCHOLINE; CHOLINERGIC SYSTEMS; CHOLINE ACETYLTRANSFERASE; REGULATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
105
Recensione:
Indirizzi per estratti:
Citazione:
D.H. Wu e L.B. Hersh, "CHOLINE-ACETYLTRANSFERASE - CELEBRATING ITS 50TH YEAR", Journal of neurochemistry, 62(5), 1994, pp. 1653-1663

Abstract

It is well known that the regulation of choline acetyltransferase (ChAT) activity under physiological and pathological conditions is important for the development and neuronal activities of cholinergic systemsinvolved in many fundamental brain functions. This review focuses on recent progress in understanding the regulation of ChAT at the levels of both the protein and the mRNA. A deficiency in ChAT activity has been reported for neurodegenerative conditions such as Alzheimer's disease, amyotrophic lateral sclerosis, and schizophrenia. Although a majorfeature of ChAT regulation is likely to involve the spatial and temporal control of transcription, regulation of expression can also be at the level of RNA processing, transport/translocation, turnover, or translation. In addition, there is increasing evidence that ChAT might beregulated at the posttranslational level by compartmentation and/or covalent modification, i.e., phosphorylation, as well as noncovalent modification (protein-protein interaction, etc.). Synaptic activity and the state of neuronal transmission may also involve the regulation of ChAT at different levels via both positive and negative feedback loops, as was demonstrated in the characterization of two ChAT mutant Drosophila strains. Clearly, identification of cholinergic-specific elements and the characterization of the trans-acting factors that bind to them represent an important area of future research. Equally important is research on the mechanisms governing ChAT as an enzymatic entity. The future should be an exciting time during which we look forward to the elucidation of the cholinergic signal and its regulation as well as the determination of the three-dimensional structure of the enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 05:48:50