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Titolo:
NEUROTRANSMITTER RECEPTORS IN FETAL TISSUE-TRANSPLANTS - EXPRESSION AND FUNCTIONAL-SIGNIFICANCE
Autore:
LU SY; NORMAN AB;
Indirizzi:
UNIV CINCINNATI,COLL MED,DEPT PSYCHIAT,DIV NEUROSCI CINCINNATI OH 45267 UNIV CINCINNATI,COLL MED,DEPT PSYCHIAT,DIV NEUROSCI CINCINNATI OH 45267 UNIV CINCINNATI,COLL MED,DEPT PHYSIOL,DIV NEUROSCI CINCINNATI OH 45267 UNIV CINCINNATI,COLL MED,DEPT ANAT,DIV NEUROSCI CINCINNATI OH 45267
Titolo Testata:
Journal of neural transplantation & plasticity
fascicolo: 3, volume: 4, anno: 1993,
pagine: 215 - 226
SICI:
0792-8483(1993)4:3<215:NRIFT->2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAINIC ACID LESIONS; UNILATERAL NEOSTRIATAL LESIONS; ADRENAL-MEDULLA GRAFTS; D2 DOPAMINE-RECEPTORS; STRIATAL GRAFTS; RAT STRIATUM; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; C-FOS;
Keywords:
DOPAMINE; SEROTONIN; BEHAVIOR; MUSCARINIC; ACETYLCHOLINE RECEPTORS; FETAL TISSUE GRAFTS; C-FOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
S.Y. Lu e A.B. Norman, "NEUROTRANSMITTER RECEPTORS IN FETAL TISSUE-TRANSPLANTS - EXPRESSION AND FUNCTIONAL-SIGNIFICANCE", Journal of neural transplantation & plasticity, 4(3), 1993, pp. 215-226

Abstract

Numerous studies have examined receptor expression in neural transplants and their possible role in transplant-induced functional recovery from lesion-induced deficits. Herein we attempt to summarize the results of these studies, especially those from studies involving striatal transplants. Autoradiographic studies indicate that dopamine D-1 and D-2, muscarinic, cholinergic, 5-HT2, opiate mu, P adrenergic and cholecystokinin (CCK) receptors are present in striatal transplants. Many ofthese receptors are present regardless of the transplant location andsurrounding environment. This suggests that the expression of these receptors is determined by intrinsic properties of transplanted tissue,and is independent of transplant location and environment. Some transplant receptors, such as dopamine D-1 and D-2 and muscarinic receptorsin striatal transplants, or 5-HT2 receptors in cortical transplants, display a patchy distribution which is dissimilar to that in the corresponding adult host tissue. This manuscript discusses this ''abnormal'' receptor distribution and possible explanations. ElectrophysiologicaI studies have indicated that some of the transplant receptors respondto physiological and pharmacological stimulation, suggesting that they are functional. However, the association of receptor expression withbehavioral recovery is uncertain. The expression of neurotransmitter receptors in neural transplants may not be essential for the functional recovery associated with trophic mechanisms. However, neurotransmitter receptors may play air important role when functional recovery requires neuroanatomical integration between the host brain and the transplanted tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:01:43