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Titolo:
USE OF IMMUNOGLOBULINS IN SEPSIS - A STAT US-REPORT
Autore:
WERDAN K; PILZ G;
Indirizzi:
UNIV HALLE WITTENBERG,LEHRSTUHL KARDIOL INTENS MED,KLIN & POLIKLIN INNERE MED 3 D-06097 HALLE GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN 1 D-8000 MUNICH GERMANY
Titolo Testata:
Infusionstherapie und Transfusionsmedizin
, volume: 23, anno: 1996, supplemento:, 4
pagine: 117 - 126
SICI:
1019-8466(1996)23:<117:UOIIS->2.0.ZU;2-#
Fonte:
ISI
Lingua:
GER
Soggetto:
GRAM-NEGATIVE BACTEREMIA; POOLED HUMAN-IGG; SEPTIC SHOCK; CLINICAL-TRIAL; BACTERIAL-INFECTIONS; MONOCLONAL-ANTIBODY; CARDIAC-SURGERY; DOUBLE-BLIND; MULTICENTER; THERAPY;
Keywords:
SEPSIS; APACHE II SCORE; CARDIAC SURGERY; SBITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
K. Werdan e G. Pilz, "USE OF IMMUNOGLOBULINS IN SEPSIS - A STAT US-REPORT", Infusionstherapie und Transfusionsmedizin, 23, 1996, pp. 117-126

Abstract

1. For the 'total population of patients with sepsis, sepsis syndromeor SIRS', the question of whether intravenous immune globulin (ivIg) reduces mortality is neither proved nor disproved. 2. For the sepsis subgroups 'postoperative sepsis with a sepsis score >19' and 'endotoxaemic, early septic shock', a significant reduction in mortality by ivIghas been documented in a single, placebo-controlled, small trial of each subgroup; subsequent studies are needed for confirmation. 3. The incidence of some severe infections in defined 'patients at risk' and 'operations at risk' is lowered by ivIg prophylaxis. 4. Postoperative APACHE II-score identification of high-risk cardiac surgery patients prone to sepsis and severe SIPS may represent one approach to optimize individual, early therapy. Applying this concept to immune globulin treatment in a pilot study, the administration of IgG-ivIg and IgGMA-ivIgyielded similar results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:15:45