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Titolo:
PRENATAL COCAINE TREATMENT REDUCES HALOPERIDOL-INDUCED CATALEPSY ON POSTNATAL DAY-10
Autore:
MEYER JS; ROBINSON P; TODTENKOPF MS;
Indirizzi:
UNIV MASSACHUSETTS,DEPT PSYCHOL,NEUROSCI & BEHAV PROGRAM,TOBIN HALL AMHERST MA 01003
Titolo Testata:
Neurotoxicology and teratology
fascicolo: 2, volume: 16, anno: 1994,
pagine: 193 - 199
SICI:
0892-0362(1994)16:2<193:PCTRHC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC DOPAMINE-RECEPTORS; DEVELOPING RAT; EXPOSURE; PREFERENCE; STRIATUM;
Keywords:
PRENATAL COCAINE; DEVELOPMENT; CATALEPSY; HALOPERIDOL; DOPAMINE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Meyer et al., "PRENATAL COCAINE TREATMENT REDUCES HALOPERIDOL-INDUCED CATALEPSY ON POSTNATAL DAY-10", Neurotoxicology and teratology, 16(2), 1994, pp. 193-199

Abstract

This study examined the influence of prenatal cocaine on subsequent cataleptic responses to the dopamine (DA) receptor antagonist haloperidol. Pregnant Sprague-Dawley rats were given daily injections of 40 mg/kg cocaine HCl SC from gestational day 8 to 20. Control animals were either uninjected and fed ad lib or saline-injected and pair-fed to thecocaine dams. On postnatal day (PD) 1, litters were culled to eight (sex-balanced if possible) and fostered to surrogate mothers. On PD 10 and PD 15, one male and one female from each litter were injected SC with 1 mg/kg haloperidol or vehicle. Each pup was tested for catalepsy 1 h later by placing its forepaws on an elevated, horizontally oriented dowel rod and recording the latency to remove at least one paw from the dowel. On PD 10 but not PD 15, haloperidol administration producedsignificantly less catalepsy in the cocaine-exposed subjects than in the untreated controls. No other group differences were observed. These results suggest that prenatal cocaine may alter either the DA systemor any of several other neurotransmitters known to influence neuroleptic-induced catalepsy.

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Documento generato il 12/07/20 alle ore 03:18:24