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Titolo:
SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES AS ANTIVIRAL AGENTS AGAINST CYTOMEGALOVIRUS
Autore:
REIST EJ; BRADFORD WW; HUFFMAN J; SIDWELL RW; RUHLANDFRITSCH BL; STURM PA; ZAVERI NT;
Indirizzi:
SRI INT,333 RAVENSWOOD AVE MENLO PK CA 94025 UTAH STATE UNIV LOGAN UT 84322
Titolo Testata:
Nucleosides & nucleotides
fascicolo: 1-3, volume: 13, anno: 1994,
pagine: 539 - 550
SICI:
0732-8311(1994)13:1-3<539:SOAPAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GANCICLOVIR; VIRUS; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Reist et al., "SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES AS ANTIVIRAL AGENTS AGAINST CYTOMEGALOVIRUS", Nucleosides & nucleotides, 13(1-3), 1994, pp. 539-550

Abstract

Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine. and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:04:06