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Titolo:
MUTAGENESIS RESCUES SPERMINE AND ZN2+ POTENTIATION OF RECOMBINANT NMDA RECEPTORS
Autore:
ZHENG X; ZHANG L; DURAND GM; BENNETT MVL; ZUKIN RS;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 10461
Titolo Testata:
Neuron
fascicolo: 4, volume: 12, anno: 1994,
pagine: 811 - 818
SICI:
0896-6273(1994)12:4<811:MRSAZP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; XENOPUS OOCYTES; REGIONAL DISTRIBUTION; ENDOGENOUS ZN-2+; CHANNEL CURRENTS; CORTICAL-NEURONS; POLYAMINES; RAT; BRAIN; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
X. Zheng et al., "MUTAGENESIS RESCUES SPERMINE AND ZN2+ POTENTIATION OF RECOMBINANT NMDA RECEPTORS", Neuron, 12(4), 1994, pp. 811-818

Abstract

Alternative splicing generates distinct forms of the NMDA receptor subunit NR1. NR1 subunits with an N-terminal insert (termed N1) form receptors in Xenopus oocytes with greatly reduced potentiation by spermine and Zn2+. Oocytes expressing NR1 receptors with N1 exhibited larger NMDA currents than oocytes expressing corresponding receptors without N1. In the present study, we used mutational analysis to investigate structural features of the N1 insert that control current amplitude andspermine and Zn2+ potentiation. Neutralization of positive charges inN1 rescued spermine and Zn2+ potentiation. Positive charges in N1 didnot affect spermine or Zn2+ affinity. Neutralization of positive charges in N1 diminished the responses to the level of NR1 receptors lacking N1. The positively charged N1 may increase NMDA currents by causinga conformational change similar to that produced by spermine and Zn2in NR1 receptors lacking N1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:22:38