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Titolo:
MECHANISMS OF THE ENHANCED CONTRACTILE RESPONSE TO PHENYLEPHRINE IN THORACIC AORTA ISOLATED FROM RATS WITH DIETARY MAGNESIUM-DEFICIENCY
Autore:
SAKAGUCHI H; NISHIO A;
Indirizzi:
KAGOSHIMA UNIV,FAC AGR,DEPT VET PHARMACOL KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC AGR,DEPT VET PHARMACOL KAGOSHIMA 890 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 4, volume: 64, anno: 1994,
pagine: 265 - 272
SICI:
0021-5198(1994)64:4<265:MOTECR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; CALCIUM CHANNELS; BINDING; INCREASES; CELLS; DEPOLARIZATION; MODULATION; MEMBRANES; AFFINITY; SITES;
Keywords:
MG-DEFICIENT RAT; PHENYLEPHRINE; NIFEDIPINE; [H-3] PN200-110 BINDING; H7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H. Sakaguchi e A. Nishio, "MECHANISMS OF THE ENHANCED CONTRACTILE RESPONSE TO PHENYLEPHRINE IN THORACIC AORTA ISOLATED FROM RATS WITH DIETARY MAGNESIUM-DEFICIENCY", Japanese Journal of Pharmacology, 64(4), 1994, pp. 265-272

Abstract

The mechanisms underlying the enhanced contractile response to phenylephrine (PE) and increased susceptibility to nifedipine of de-endothelialized thoracic aorta isolated from rats with dietary magnesium deficiency (Mg-deficient rats) were examined by functional and radioligand binding studies. Enhanced PE-induced contractions and increased susceptibility to nifedipine in Mg-deficient rats were not observed in the presence of 10 mu M H7. PE significantly decreased the K-D value without changing B-max in the binding of H-3PN200-110 to de-endothelialized aortic strips. The K-D value obtained in the Mg-deficient rats was significantly smaller than that in the controls. Nifedipine displaced the binding of H-3PN200-110 concentration-dependently, and the pK(i) value in Mg-deficient rats was significantly larger than that in the controls. A combination of PE and H7 abolished this difference. These results indicate that the modulation of L-type Ca2+ channels via the stimulation of alpha(1)-adrenoceptors may be involved in the enhancementof vasoconstriction and increased susceptibility to nifedipine in aortas isolated from Mg-deficient rats. The H7-sensitive mechanisms may play an important role in these phenomena.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:08:22