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Titolo:
GALLINACINS - CYSTEINE-RICH ANTIMICROBIAL PEPTIDES OF CHICKEN LEUKOCYTES
Autore:
HARWIG SSL; SWIDEREK KM; KOKRYAKOV VN; TAN L; LEE TD; PANYUTICH EA; ALESHINA GM; SHAMOVA OV; LEHRER RI;
Indirizzi:
UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT MED,10833 LECONTE AVE LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,CTR HLTH SCI,DEPT MED LOS ANGELES CA 90024 CITY HOPE NATL MED CTR,BECKMAN RES INT,DIV IMMUNOL DUARTE CA 91010 ST PETERSBURG EXPTL MED INST,DEPT GEN PATHOL & PATHOPHYSIOL 19736 ST PETERSBURG RUSSIA
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 342, anno: 1994,
pagine: 281 - 285
SICI:
0014-5793(1994)342:3<281:G-CAPO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBACTERIAL PEPTIDES; PIG INTESTINE; NEUTROPHILS; POLYPEPTIDES; HEMOCYTES; PROTEINS; SEQUENCE;
Keywords:
ANTIMICROBIAL PEPTIDE; BETA-DEFENSIN; CHICKEN LEUKOCYTE; LC-ESI MASS SPECTROMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
S.S.L. Harwig et al., "GALLINACINS - CYSTEINE-RICH ANTIMICROBIAL PEPTIDES OF CHICKEN LEUKOCYTES", FEBS letters, 342(3), 1994, pp. 281-285

Abstract

We purified three homologous antimicrobial peptides ('gallinacins') from chicken leukocytes, examined their antimicrobial activity in vitro, and established their primary sequences by a combination of gas phase microsequencing and on-line LC-ESI-MS analysis of endo- and exoprotease peptide digests. The peptides contained 36-39 amino acid residues,were relatively cationic due to their numerous lysine and arginine residues, and each contained 3 intramolecular cystine disulfide bonds. Gallinacins showed primary sequence homology to the recently delineatedbeta-defensin family, heretofore found only in the respiratory epithelial cells and neutrophils of cattle, suggesting that beta-defensins originated at least 250 million years ago, before avian and mammalian lineages diverged. The 9 invariant residues (6 cysteines, 2 glycines and 1 proline) common to avian gallinacins and bovine beta-defensins arelikely to constitute the essential primary structural motif of this ancient family of host-defense peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:58:07