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Titolo:
TAP POLYMORPHISMS IN SWEDISH MYASTHENIA-GRAVIS PATIENTS
Autore:
HJELMSTROM P; GISCOMBE R; LEFVERT AK; PIRSKANEN R; KOCKUM I; LANDINOLSSON M; SANJEEVI CB;
Indirizzi:
KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOL MED,M3 00 S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOL MED,M3 00 S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT MED S-17176 STOCKHOLM SWEDEN KAROLINSKA INST,SODERSJUKHUSET HOSP,DEPT NEUROL STOCKHOLM SWEDEN UNIV LUND HOSP,DEPT MED S-22185 LUND SWEDEN
Titolo Testata:
Tissue antigens
fascicolo: 2, volume: 49, anno: 1997,
pagine: 176 - 179
SICI:
0001-2815(1997)49:2<176:TPISMP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II REGION; LINKAGE DISEQUILIBRIUM; DISEASE HETEROGENEITY; HLA; ASSOCIATIONS; RECOMBINATION; HAPLOTYPES; GENES;
Keywords:
HLA-DQ2; HLA-DR3; MYASTHENIA GRAVIS; STRATIFICATION ANALYSIS; TAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
P. Hjelmstrom et al., "TAP POLYMORPHISMS IN SWEDISH MYASTHENIA-GRAVIS PATIENTS", Tissue antigens, 49(2), 1997, pp. 176-179

Abstract

The association between myasthenia gravis (MG) and TAP polymorphisms was studied in 79 Swedish patients and 155 unrelated controls. TAP typing was performed by ARMS-PCR technique and stratification analysis was used to determine if the TAP associations were independent or secondary to linkage disequilibrium with DQ2 and DR3. TAP1 and TAP2 alleles did not confer independent risk for MG. TAP20101 was, however, positively associated with MG in patients with an early onset of disease compared to patients with a late onset of disease. TAP1 and TAP2 alleles did not confer risk in MG patients negative for DQ2. In conclusion, susceptibility to MG is not primarily conferred by TAP alleles in the extended DR3 haplotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:30:12