Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXERCISE ELECTROCARDIOGRAPHY AND AORTIC DOPPLER VELOCIMETRY IN ASYMPTOMATIC IDENTICAL-TWINS DISCORDANT FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES
Autore:
DUBREY S; AKHRAS F; SONG GJ; HARDMAN T; TRAVILL C; HYND J; NOBLE MIM; LO SSS; LESLIE RDG;
Indirizzi:
CHELSEA & WESTMINSTER HOSP,CHARING CROSS & WESTMINSTER MED SCH,DEPT ACAD MED,369 FULHAM RD LONDON SW10 9NH ENGLAND ST MARYS HOSP,DEPT CARDIOL LONDON W2 1NY ENGLAND DEPT DIABET & METAB LONDON ENGLAND
Titolo Testata:
British Heart Journal
fascicolo: 4, volume: 71, anno: 1994,
pagine: 341 - 348
SICI:
0007-0769(1994)71:4<341:EEAADV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR STRUCTURE; QT INTERVAL PROLONGATION; SUDDEN CARDIAC DEATH; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; AUTONOMIC NEUROPATHY; RISK-FACTORS; HEART-RATE; MELLITUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
S. Dubrey et al., "EXERCISE ELECTROCARDIOGRAPHY AND AORTIC DOPPLER VELOCIMETRY IN ASYMPTOMATIC IDENTICAL-TWINS DISCORDANT FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES", British Heart Journal, 71(4), 1994, pp. 341-348

Abstract

Objective-To determine the influence of insulin dependent diabetes onthe prevalence of myocardial ischaemia and on global left ventricularsystolic performance. Design-Stress treadmill electrocardiograms and simultaneous Doppler measurement of aortic maximum acceleration were obtained during exercise on symptom free subjects. The electrocardiograms were scored blindly according to the Minnesota code. Participants-39 identical twin pairs (22 male) discordant for insulin dependent diabetes and 39 non-diabetic controls of similar age and sex were examined. The twins and controls had a mean age of 37 (range 25-69) with a mean (SD) duration of diabetes in the diabetic twin of 17 (7) years. Those selected were normotensive and had no renal impairment. Results-Systolic blood pressure was significantly higher in the diabetic twins than in their non-diabetic cotwins both at rest (p < 0.05) and at peak exercise (p < 0.01). Electrocardiographic evidence of ischaemia was not correlated within twin pairs and was found in similar numbers of diabetic twins, their non-diabetic cotwins, and control subjects. Abnormal electrocardiograms were found in a similar number of diabetic twins (23%), non-diabetic cotwins (18%), and controls (15%). There was a significant correlation in Doppler measurements of global left ventricular systolic function within the identical twins; no significant difference was found for these Doppler measurements in the diabetic twins, non-diabetic cotwins, or controls. Conclusion-Exercise characteristics andcardiac function seem to be subject to shared genetic or shared environmental influences or both, whereas electrocardiographic features of ischaemia seem to be environmentally determined. In a selected cohort of diabetic identical twins without evidence of nephropathy there was no evidence that diabetes influenced the prevalence of myocardial ischaemia or global left ventricular systolic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:09:56