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Titolo:
CLEARANCE STUDY FOR THE ESTIMATION OF GLOMERULAR-FILTRATION OF CD FOLLOWING THE INTRAVENOUS BOLUS OF CDCL2 AND CD-SATURATED METALLOTHIONEIN-II IN RATS
Autore:
HAYASHI T; TERUI J; SUDO J;
Indirizzi:
HIGASHI NIPPON GAKUEN UNIV,FAC PHARMACEUT SCI,DEPT CLIN PHARMACOL & TOXICOL ISHIKARI HOKKAIDO 06102 JAPAN HIGASHI NIPPON GAKUEN UNIV,FAC PHARMACEUT SCI,DEPT CLIN PHARMACOL & TOXICOL ISHIKARI HOKKAIDO 06102 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 4, volume: 17, anno: 1994,
pagine: 557 -
SICI:
0918-6158(1994)17:4<557:CSFTEO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CADMIUM-METALLOTHIONEIN; KIDNEY; NEPHROPATHY; BINDING;
Keywords:
CADMIUM; METALLOTHIONEIN; RENAL CLEARANCE; NEPHROTOXICITY; GLOMERULAR FILTRATION; RAT;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
T. Hayashi et al., "CLEARANCE STUDY FOR THE ESTIMATION OF GLOMERULAR-FILTRATION OF CD FOLLOWING THE INTRAVENOUS BOLUS OF CDCL2 AND CD-SATURATED METALLOTHIONEIN-II IN RATS", Biological & pharmaceutical bulletin, 17(4), 1994, pp. 557

Abstract

A clearance study of Cd was carried out in rats that had received an intravenous bolus of CdCl2 or Cd-saturated metallothionein-II (Cd-MT-II) at 0.3 mg Cd/kg body weight. Urinary concentrations of Cd, and those corrected by the urine-plasma inulin ratio, were higher, by 2 or 3 orders of magnitude, for Cd-MT-II than for CdCl2. Fractional clearance of Cd was 0.0006 to 0.0029 for CdCl2, and 0.130 to 0.487 for Cd-MT-II. These findings denoted that the glomerular filtration of Cd was greater in the Cd-MT-II administration than in CdCl2 administration. This difference in the glomerular filtration of Cd gave a clear explanation for the greater nephrotoxic potential of Cd-MT-II. Also, our data revealed that when Cd was administered as Cd-MT-II, the concentration of Cd was 20 to 70 times higher at the end-point of the renal tubules thanat its starting-point. This and the histopathological reports so far strongly suggest that the distally located tubules are highly resistant to intraluminal Cd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:53:50