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Titolo:
SELECTIVE ROLES FOR HIPPOCAMPAL, PREFRONTAL CORTICAL, AND VENTRAL STRIATAL CIRCUITS IN RADIAL-ARM MAZE TASKS WITH OR WITHOUT A DELAY
Autore:
FLORESCO SB; SEAMANS JK; PHILLIPS AG;
Indirizzi:
UNIV BRITISH COLUMBIA,DEPT PSYCHOL,2136 W MALL VANCOUVER BC V6T 1Z4 CANADA UNIV BRITISH COLUMBIA,DEPT PSYCHOL VANCOUVER BC V6T 1Z4 CANADA
Titolo Testata:
The Journal of neuroscience
fascicolo: 5, volume: 17, anno: 1997,
pagine: 1880 - 1890
SICI:
0270-6474(1997)17:5<1880:SRFHPC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS LEUCOAGGLUTININ; ANTEROGRADE TRANSPORT; NUCLEUS-ACCUMBENS; WORKING-MEMORY; SPATIAL MEMORY; CORTEX; RAT; LESIONS; MONKEYS; DISCONNECTION;
Keywords:
VENTRAL CA1/SUBICULUM; PRELIMBIC CORTEX; NUCLEUS ACCUMBENS; SPATIAL MEMORY; NEURAL NETWORKS; LIDOCAINE-INDUCED REVERSIBLE LESIONS; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Floresco et al., "SELECTIVE ROLES FOR HIPPOCAMPAL, PREFRONTAL CORTICAL, AND VENTRAL STRIATAL CIRCUITS IN RADIAL-ARM MAZE TASKS WITH OR WITHOUT A DELAY", The Journal of neuroscience, 17(5), 1997, pp. 1880-1890

Abstract

The hippocampus, the prefrontal cortex, and the ventral striatum forminterconnected neural circuits that may underlie aspects of spatial cognition and memory. In the present series of experiments, we investigated functional interactions between these areas in rats during the performance of delayed and nondelayed spatially cued radial-arm maze tasks. The two-phase delayed task consisted of a training phase that provided rats with information about where food would be located on the maze 30 min later during a test phase. The single-phase nondelayed task was identical to the test phase of the delayed task, but in the absence of a training phase rats lacked previous knowledge of the location of food on the maze. Transient inactivation of the ventral CA1/subiculum (vSub) by a bilateral injection of lidocaine disrupted performance on both tasks. Lidocaine injections into the vSub on one side of the brain and the prefrontal cortex on the other transiently disconnected these two brain regions and significantly impaired foraging during the delayed task but not the nondelayed task. Transient disconnections between the vSub and the nucleus accumbens produced the opposite effect, disrupting foraging during the nondelayed task but not during the delayed task. These data suggest that serial transmission of information between the vSub and the prefrontal cortex is required when trial-unique, short-term memory is used to guide prospective search behavior. In contrast, exploratory goal-directed locomotion in a novel situation notrequiring previously acquired information about the location of food is dependent on serial transmission between the hippocampus and the nucleus accumbens. These results indicate that different aspects of spatially mediated behavior are subserved by separate, distributed limbic-cortical-striatal networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:11:07