Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE EFFECT OF NITRIC-OXIDE SYNTHASE INHIBITION ON THE PLASMA FIBRINOLYTIC SYSTEM IN SEPTIC SHOCK IN RATS
Autore:
KORBUT R; WARNER TD; GRYGLEWSKI RJ; VANE JR;
Indirizzi:
UNIV LONDON ST BARTHOLOMEWS HOSP & MED COLL,WILLIAM HARVEY RES INST,CHARTERHOUSE SQ LONDON EC1M 6BQ ENGLAND JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL PL-31531 KRAKOW POLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 1, volume: 112, anno: 1994,
pagine: 289 - 291
SICI:
0007-1188(1994)112:1<289:TEONSI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR; COAGULATION; HYPOTENSION; INVIVO;
Keywords:
LIPOPOLYSACCHARIDE; FIBRINOLYSIS; DISSEMINATED INTRAVASCULAR COAGULATION (DIC); PLASMINOGEN ACTIVATOR INHIBITOR (PAI); NITRIC OXIDE SYNTHASE INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R. Korbut et al., "THE EFFECT OF NITRIC-OXIDE SYNTHASE INHIBITION ON THE PLASMA FIBRINOLYTIC SYSTEM IN SEPTIC SHOCK IN RATS", British Journal of Pharmacology, 112(1), 1994, pp. 289-291

Abstract

1 We have investigated the effect of pretreatment of rats with nitricoxide (NO) synthase inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME) on the E. coli lipopolysaccharide (LPS)-induced changes in the plasma frbrinolytic system, platelet count, fibrinogen level, as well asin gross and microscopic pathophysiological changes indicative of disseminated intravascular coagulation (DIC) in rats. 2 E. coli LPS (6 mgkg(-1), i.p.) produced a decrease in the levels of plasma fibrinogen and a drop in the blood platelet count 6h after administration. The decrease in fibrinogen but not the drop in platelet count was reversed by pretreatment with L-NAME (30 mg kg(-1), i.p., 24 h and 15 min beforeadministration of LPS). 3 Pretreatment with L-NAME antagonized the LPS-induced activation of fibrinolysis as measured by changes in the euglobulin clot lysis time (ECLT) and enhanced the LPS-induced rise in the plasma level of plasminogen activator inhibitor (PAI). In animals pretreated with L-NAME there was also a marked reduction in the histological changes indicative of DIC. 4 We propose that L-NAME can act as a protective agent in LPS-induced DIC, and this protection is due to an increased generation of PAI following inhibition of NO synthase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:20:06