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Titolo:
PROOPIOMELANOCORTIN GENE-EXPRESSION DURING PIG PITUITARY AND BRAIN-DEVELOPMENT
Autore:
MA E; MILEWSKI N; GROSSMANN R; IVELL R; KATO Y; ELLENDORFF F;
Indirizzi:
FAL,INST SMALL ANIM RES,DORNBERGSTR 25-27 D-29223 CELLE GERMANY FAL,INST SMALL ANIM RES D-29223 CELLE GERMANY FAL,INST ANIM SCI & ANIM BEHAV D-31535 NEUSTADT GERMANY INST HORMONE & FERTIL RES D-22529 HAMBURG GERMANY GUNMA UNIV,INST ENDOCRINOL MAEBASHI GUMMA 371 JAPAN
Titolo Testata:
Journal of neuroendocrinology
fascicolo: 2, volume: 6, anno: 1994,
pagine: 201 - 209
SICI:
0953-8194(1994)6:2<201:PGDPPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOMELANOCORTIN MESSENGER-RNA; POLYPEPTIDE HORMONES ACTH; RAT PITUITARY; INTERMEDIATE LOBE; ANTERIOR-PITUITARY; BETA-ENDORPHIN; GLUCOCORTICOID REGULATION; SYNERGISTIC INTERACTIONS; HYPOTHALAMUS; ONTOGENY;
Keywords:
PIG; PROOPIOMELANOCORTIN; IN SITU HYBRIDIZATION; PITUITARY; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
E. Ma et al., "PROOPIOMELANOCORTIN GENE-EXPRESSION DURING PIG PITUITARY AND BRAIN-DEVELOPMENT", Journal of neuroendocrinology, 6(2), 1994, pp. 201-209

Abstract

The expression of proopiomelanocortin (POMC) mRNA, which plays an important role in neural, endocrine, neuroendocrine and immune systems, was studied by in situ hybridization during the development of pituitary in the domestic pig. The POMC gene was activated as early as fetal day 30 (E30). The signal for POMC mRNA in the anterior lobe progressively increased from E30 to E80 and then remained at relatively constant level. In contrast, POMC transcripts in the intermediate lobe first appeared at E40 and steadily increased during development. POMC transcripts in the brain were first found at E40 and were scattered in the arcuate nucleus (AN) and nucleus medialis thalami (NMT). At E50 the extra-pituitary POMC mRNA was located not only in the AN and NMT but also in the fasciulus tegmenti and entorhinal cortex. In the posterior lobe,no signal was detected. The specific pattern of expression of the pigPOMC gene in the pituitary and in specific regions of the central nervous system suggests important roles for POMC in fetal development. These results also suggest that POMC is excellent for studying the expression and regulation of pituitary hormone genes because of its tissue-specific regulation and developmental pattern.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:44:30