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Titolo:
STEREOSELECTIVE SYNTHESIS OF ETHYLETHYLSULFONYLMETHYL)-3-(1-NAPHTHYL)-PROPIONIC ACID, BUILDING-BLOCK FOR PROTEASE INHIBITORS VIA ASYMMETRICHYDROGENATION
Autore:
BECK G; JENDRALLA H; KAMMERMEIER B;
Indirizzi:
HOECHST AG,ALLGEMEINE PHARMA FORSCH,POSTFACH 800320 D-65926 FRANKFURT80 GERMANY
Titolo Testata:
Tetrahedron
fascicolo: 16, volume: 50, anno: 1994,
pagine: 4691 - 4698
SICI:
0040-4020(1994)50:16<4691:SSOE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
G. Beck et al., "STEREOSELECTIVE SYNTHESIS OF ETHYLETHYLSULFONYLMETHYL)-3-(1-NAPHTHYL)-PROPIONIC ACID, BUILDING-BLOCK FOR PROTEASE INHIBITORS VIA ASYMMETRICHYDROGENATION", Tetrahedron, 50(16), 1994, pp. 4691-4698

Abstract

Title compound 1b (purity > 99%, 99.6% ee) is synthesized (100g scale) from commercial( 3-bromo-pyruvic acid in six steps with an overall yield of l6%. The sequence is operationally simple and devoid of chromatographic purifications. Key step is the asymmetric hydrogenation of asubstrate with sulfur functionality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 14:43:02