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Titolo:
PROGNOSTIC-SIGNIFICANCE OF LEFT-VENTRICULAR ANEURYSM IN THE CARDIAC-ARRHYTHMIA-SUPPRESSION-TRIAL (CAST) POPULATION
Autore:
HOCHMAN JS; BROOKS AMM; MORRIS BM; AHMAD T; ROGERS WJ; EPSTEIN AE; ARCINIEGAS JG; CROSSLEY GH; DAILEY SM; KAY GN; LITTLE RE; MACLEAN WAH; PAPAPIETRO SE; PLUMB VJ; SILBER S; BAKER AR; CARLISLE K; COHEN N; COX M; THOMAS C; LEVSON L; VONHAGEL D; WALTON AE; PRATT CM; MAHMARIAN J; MORRIS G; CAPONE RJ; BERGER EE; CHMIELEWSKI C; GORKIN L; KHAN AH; KORR K; HANDSHAW K; CONNOLLY E; FITZPATRICK D; CAMERON T; WYSE DG; DUFF HJ; MITCHELL LB; GILLIS AM; WARNICA JW; SHELDON RS; LESOWAY NR; KELLEN J; HALE C; INKSTER M; BRODSKY M; WOLFF L; ALLEN B; ZELMAN R; THOMAS G; CAUDILLO G; TAKEDA D; SHERWOOD C; RANAZZI R; RAPAPORT E; DOHRMANN ML; RASKIN S; DREW DW; SOMELOFSKI CA; DANFORTH JW; KUI PY; JOHNSON MR; LABARCA JR; WALDO AL; CARLSON MD; ADLER DS; HOLLAND JB; BUCHTER CM; BAHLER RC; PAMELIA FX; JOSEPHSON RA; HENTHORN RW; ZUELGARAY JG; WOOD K; REDMON P; VARGAS MA; VARGO L; SCHALLER SE; KOBUS CE; CHOBAN NL; BIGGER NYJ; GREENBERG HM; GREGORY JJ; RADOSLOVICH G; STEINBERG JS; ROTHBART ST; CASE R; DWYER EM; SQUATRITO A; KELLY M; CAMPION JM; TORMEY D; ANTHONY R; CALLAGHAN E; CHAPNICK M; RIPLEY B; FONTANA C; SCHLANT RC; ARENSBERG D; CORSO JA; HURST JW; MORRIS DC; SHERMAN SW; SILVERMAN BD; SILVERMAN ME; ROBERTS JS; BALLOU SK; JEFFRIES VD; BRACKNEY BA; SEALS AA; HARTLEY J; BAKER RM; GILMOUR KE; BAKER SB; HOWARD J; KATZ RJ; BESCH GA; BRILL D; DIBIANCO R; DONOHUE D; FISHER G; FRANCIS C; FRIEDMAN D; GOLDBERG D; GOLDBERG S; KOSS G; LARCA L; LEONARD R; LINDGREN K; RONAN J; ROSENBLATT A; ROSING D; ROSS A; ROTSZTAIN A; SHAWL F; SINDERSON T; STEVENSON R; TINKER B; VARGHESE J; YACKEE J; BIGHAM H; FRANKLIN W; GOLD R; GRAHAM G; GROSSBERG D; HOARE R; LEVY W; MAHMOOD T; TANNENBAUM E; TULLNER W; EISENHOWER E; GERACI T; WILHELMSEN L; BERGSTRAND R; FREDLUND BO; SIGURDSSON A; SIVERTSSON R; SWEDBERG K; HOULTZ B; WIKLUND I; SCHLYTER G; HEDELIN G; LEIJON M; MORGANROTH J; CARVER J; HOROWITZ L; KUTALEK S; PAPA L; SANDBERG J; VICTOR M; CESARE S; VRABEL C; TALARICO K; LUHMANN S; PALAZZO D; GOLDSTEIN S; GOLDBERG AD; FRUMIN H; WESTVEER D; DEBUTLIER M; SCHAIRER J; STOMEL R; FRANK DM; JARANDILLA R; DAVEY D; HASSE C; SHINNEY S; MORLEDGE JH; FARNHAM DJ; HINDERACKER PH; MUSSER WE; DEVRIES K; KUSHNER JA; RAO R; PETERSON DT; MCCAULEY CS; BERGEN TS; BOWMAN KO; GILLMAN A; FULLER L; OBRIEN J; MORLEDGE J; DEMARIA AN; KUO CS; KAMMERLING JM; CORUM J; THIEMANN M; SCHRODT R; PETERS R; SUTTON F; GOTTLIEB S; PAPUCHIS G; MATTIONI T; TODD L; CUSACK C; SCHECK J; HUANG SKS; ALPERT JS; GORE JM; RYAN M; COLLETTWILLEY P; CHAHINE RA; SEQUEIRA RF; LOWERY MH; DELGADO LM; CORREA JL; LASO LJ; HODGES M; SALERNO D; ANDERSON B; COLLINS R; DENES P; DUNBAR D; GRANRUD G; HAUGLAND J; HESSION W; MCBRIDE J; GORNICK C; SIMONSON J; TOLINS M; ETTINGER A; PETERSON S; SLIVKEN R; GRIMALDI L; ROY D; THEROUX P; LEMERY R; MORISSETTE D; BEAUDOIN D; GIRARD L; LAVALLEE E; MCANULTY JH; REINHART SE; MAURICE G; MURPHY ES; KRON J; MARCHANT C; BOXER J; PRINCEHOUSE L; SINNER K; BEANLANDS D; DAVIES R; GREEN M; WILLIAMS W; BAIRD MJ; GARRARD L; HEAL S; HASPECT A; BORTHWICK J; MAROIS L; WOODEND K; AKIYAMA T; HOOD WB; EASLEY R; RYAN G; KENIEN G; PATT M; KAZIERAD D; GOLDFARB A; BUTLER LL; KELLER ML; STANLEY P; PEEBLES J; SYROCKI D; LAVIN D; SCHOENBERGER JA; LIEBSON PR; STAMATO NJ; PETROPULOS PR; BUCKINGHAM TA; REMIJAS T; KOCOUREK J; JANKO K; BARKER AH; ANDERSON JL; FOWLES RE; KEITH TB; WILLIAMS CB; MORENO FL; DORAN EN; FOWLER B; SUMMERS K; WHITE C; OHARA G; ROULEAU JL; PLANTE S; VINCENT C; BOUCHARD D; ZOBLE RG; OTERO JE; BUGNI WJ; SCHWARTZ KM; SHETTIGAR UR; BREWINGTON JA; UMBERGER J; COHEN JD; BJERREGAARD P; HAMILTON WP; GARNER M; ANDERSON S; ELSHERIF N; URSELL SN; GABOR GE; IBRAHIM B; ASSADI M; BREZSNYAK ML; PORTER AV; STANIORSKI A; WOOSLEY RL; RODEN DM; CAMPBELL WB; ECHT DS; LEE JT; MURRAY KT; SPELL JD; BONHOTAL ST; JARED LL; THOMAS TI; GOLDNER F; RICHARDSON DW; ROMHILT DW; ELLENBOGEN KA; BANE BB; FIELDS J; SHRADER S; POWELL E; CHAFFIN CF; WELLS A; CONWAY KT; PLATIA EV; ODONOGHUE S; TRACY CM; ALI N; BOWEN P; BROOKS KM; OETGEN W; WESTON LT; CARSON P; OBIASMANNO D; HARRISON J; SAYLOR A; POWELL S; HAAKENSON CM; SATHER MR; MALONE LA; HALLSTROM AP; MCBRIDE R; GREENE HL; BROOKS MM; LEDINGHAM R; REYNOLDSHAERTLE R; HUTHER M; SCHOLZ M; MORRIS M; FRIEDMAN LM; SCHRON E; VERTER J; JENNINGS C; PROSCHAN M; BRISTOW JD; DEMETS DL; FISCH C; NIES AS; RUSKIN J; STRAUSS H; WALTERS L;
Indirizzi:
ST LUKES ROOSEVELT HOSP,DIV CARDIOL,AMSTERDAM AVE & 114TH ST,FLOOR S&R3,ROOM 8-325 NEW YORK NY 10025 COLUMBIA UNIV,COLL PHYS & SURG NEW YORK NY 00000 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 00000 UNIV ALABAMA BIRMINGHAM AL 00000 BAYLOR COLL MED HOUSTON TX 00000 BROWN UNIV,AFFILIATED HOSP CTR PROVIDENCE RI 00000 UNIV CALGARY & COOPERATING HOSP CALGARY AB CANADA UNIV CALIF IRVINE,IRVINE MED CTR ORANGE CA 92668 UNIV CALIF SAN FRANCISCO,SAN FRANCISCO AFFILIATED HOSP SAN FRANCISCO CA 00000 CASE WESTERN RESERVE UNIV CLEVELAND OH 00000 COLUMBIA UNIV AFFILIATED HOSP NEW YORK NY 00000 EMORY UNIV,SCH MED ATLANTA GA 00000 UNIV FLORIDA JACKSONVILLE FL 00000 GEORGE WASHINGTON UNIV,MED CTR WASHINGTON DC 20037 GOTHENBURG UNIV GOTHENBURG SWEDEN HAHNEMANN UNIV PHILADELPHIA PA 00000 HENRY FORD HOSP DETROIT MI 00000 JACKSON FDN MED EDUC & RES MADISON WI 00000 UNIV KENTUCKY LEXINGTON KY 00000 UNIV MARYLAND BALTIMORE MD 00000 UNIV MASSACHUSETTS WORCESTER MA 00000 UNIV MIAMI MIAMI FL 00000 UNIV MINNESOTA MINNEAPOLIS MN 00000 MONTREAL HEART INST MONTREAL PQ CANADA OREGON HLTH SCI UNIV PORTLAND OR 00000 UNIV OTTAWA,INST HEART OTTAWA ON CANADA UNIV ROCHESTER ROCHESTER NY 00000 RUSH PRESBYTERIAN ST LUKES MED CTR CHICAGO IL 00000 SALT LAKE CLIN,RES FDN SALT LAKE CITY UT 00000 UNIV SHERBROOKE,CHUS SHERBROOKE PQ CANADA UNIV S FLORIDA TAMPA FL 00000 ST LOUIS UNIV,MED CTR ST LOUIS MO 00000 SUNY HLTH SCI CTR BROOKLYN NY 00000 VANDERBILT UNIV NASHVILLE TN 00000 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA RICHMOND VA 23298 WASHINGTON HOSP CTR WASHINGTON DC 00000 DRUG DISTRIBUT CTR,VET ADM COOPERAT STUDIES PROGRAM,CTR CLIN RES PHARM COORDINAT ALBUQUERQUE NM 00000 UNIV WASHINGTON,CTR COORDINAT SEATTLE WA 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,CLIN TRIALS BRANCH,PROGRAM OFF BETHESDA MD 20892 UNIV WISCONSIN MADISON WI 00000 INDIANA UNIV,SCH MED,KRANNERT INST CARDIOL INDIANAPOLIS IN 46202 UNIV COLORADO,SCH MED DENVER CO 00000 HARVARD UNIV,SCH MED BOSTON MA 00000 DUKE UNIV,MED CTR DURHAM NC 00000 GEORGETOWN UNIV,KENNEDY INST ETH WASHINGTON DC 20057
Titolo Testata:
The American heart journal
fascicolo: 4, volume: 127, anno: 1994,
parte:, 1
pagine: 824 - 832
SICI:
0002-8703(1994)127:4<824:POLAIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; EXPANSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Hochman et al., "PROGNOSTIC-SIGNIFICANCE OF LEFT-VENTRICULAR ANEURYSM IN THE CARDIAC-ARRHYTHMIA-SUPPRESSION-TRIAL (CAST) POPULATION", The American heart journal, 127(4), 1994, pp. 824-832

Abstract

Left ventricular aneurysm has been associated with increased mortality rates. The Cardiac Arrhythmia Suppression Trial (CAST) database was used prospectively to assess (1) the prognostic significance of left ventricular (LV) aneurysm after myocardial infarction on mortality rates and (2) the relation of LV aneurysm to ventricular arrhythmias and their suppressibility. All patients in the CAST study were enrolled after myocardial infarction. They had greater than or equal to 6 ventricular premature depolarizations (VPDs) per hour and ejection fraction less than or equal to 55%; they were enrolled in the study an average of96 days after the index myocardial infarction. Of 2494 patients with wall motion data, 164 had LV aneurysm, 600 had only dyskinesis, 913 had only akinesis, and 817 had none of these. Radionuclide scan was usedin 39%, two-dimensional echocardiography in 30%, and LV angiogram in 31%. Baseline VPDs and nonsustained ventricular tachycardia were similar in all groups. LV aneurysm patients were more frequently eliminatedduring open-label titration. The incidence of sustained VT during follow-up was only 2.8% for aneurysm patients, a rate that was similar tothe other groups. Patients with LV aneurysm had significantly lower survival rates (82% vs 91%) at 16 months after study entry than those without these wall motion abnormalities (p < 0.005). When survival rates were adjusted for ejection fraction there was still a moderately large hazard ratio (1.34) of LV aneurysm that was not statistically significant (p = 0.18). We conclude that (1) the presence of LV aneurysm does not independently worsen prognosis, and (2) older concepts of LV aneurysm and ventricular arrhythmias must be reevaluated.

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Documento generato il 29/11/20 alle ore 00:47:48