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Titolo:
EFFECTS OF CAPTOPRIL THERAPY AFTER LATE REPERFUSION ON LEFT-VENTRICULAR REMODELING AFTER EXPERIMENTAL MYOCARDIAL-INFARCTION
Autore:
JAIN P; KORLIPARA G; MALLAVARAPU C; SIKAND V; LILLIS O; COHN PF;
Indirizzi:
SUNY STONY BROOK,HLTH SCI CTR,DEPT MED,DIV CARDIOL,T-17,ROOM 020 STONY BROOK NY 11794 SUNY STONY BROOK,HLTH SCI CTR,DEPT MED,DIV CARDIOL STONY BROOK NY 11794
Titolo Testata:
The American heart journal
fascicolo: 4, volume: 127, anno: 1994,
parte:, 1
pagine: 756 - 763
SICI:
0002-8703(1994)127:4<756:EOCTAL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE PLASMINOGEN-ACTIVATOR; CORONARY-ARTERY REPERFUSION; 12-MONTH FOLLOW-UP; THROMBOLYTIC THERAPY; RANDOMIZED TRIAL; LATE POTENTIALS; SURVIVAL; DYSFUNCTION; REDUCTION; MORTALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
P. Jain et al., "EFFECTS OF CAPTOPRIL THERAPY AFTER LATE REPERFUSION ON LEFT-VENTRICULAR REMODELING AFTER EXPERIMENTAL MYOCARDIAL-INFARCTION", The American heart journal, 127(4), 1994, pp. 756-763

Abstract

Reperfusion that is too late to salvage ischemic myocardium reduces early infarct expansion, and captopril therapy favorably alters long-term left ventricular remodeling. To study whether the beneficial effects of these two therapies are additive, we examined the effects of captopril therapy after late reperfusion on left ventricular remodeling after acute myocardial infarction. Female Sprague-Dawley rats (n = 67) were randomly assigned to one of four groups: group 1, sham surgery andno treatment; group 2, left coronary artery ligation and no treatment(myocardial infarction r MI); group 3, left coronary artery ligation, reperfusion 2 hours later, and no treatment (late reperfusion LR); and group 4, left coronary artery ligation, reperfusion 2 hours later, and captopril treatment (LR-Cap). Captopril therapy (2 gm/L of drinking water) was begun in the LR-Cap group in the immediate post-operative period and continued for 20 days. Twenty-one days postoperatively,hemodynamic measurements were made before and after volume loading. The rats were killed, their hearts were removed, and passive pressure-volume curves were obtained. The hearts were then fixed at a constant pressure for morphometric analysis. Compared with the MI group, the LR group had a lower expansion index and a higher thinning ratio. There were no differences in hemodynamics, left ventricular volumes, or othermorphometric indexes between the two groups. Compared with the MI andLR groups, the LR-Cap group had lower peak left ventricular end-diastolic pressure, lower left ventricular volume, lower left and right ventricular weights, and a leftward shift of pressure-volume curves. There were no differences in the expansion index or the thinning ratio between the LR and LR-Cap groups. Thus captopril therapy after late reperfusion additionally improves hemodynamics, attenuates left ventricularcavity dilation, attenuates an increase in left and right ventricularweights, and alters the pressure-volume relationship of the left ventricle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:10:19