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Titolo:
GLUTAMATE ANTAGONISTS HAVE DIFFERENT EFFECTS ON SPONTANEOUS LOCOMOTOR-ACTIVITY IN RATS
Autore:
DANYSZ W; ESSMANN U; BRESINK I; WILKE R;
Indirizzi:
MERZ & CO,DEPT PHARMACOL,POSTFACH 111353 D-60048 FRANKFURT GERMANY
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 48, anno: 1994,
pagine: 111 - 118
SICI:
0091-3057(1994)48:1<111:GAHDEO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONISTS; D-ASPARTATE ANTAGONISTS; PHENCYCLIDINE-LIKE; HYDROCHLORIDE MCI-2016; D-CYCLOSERINE; COCAINE-LIKE; CGP 37849; GLYCINE; MK-801; BRAIN;
Keywords:
NMDA ANTAGONISTS; AMPA ANTAGONISTS; LOCOMOTOR ACTIVITY; ATAXIA; STEREOTYPY; RECEPTOR BINDING; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
W. Danysz et al., "GLUTAMATE ANTAGONISTS HAVE DIFFERENT EFFECTS ON SPONTANEOUS LOCOMOTOR-ACTIVITY IN RATS", Pharmacology, biochemistry and behavior, 48(1), 1994, pp. 111-118

Abstract

Locomotor activity, ataxia, and stereotypy were assessed in the open field after administration of NMDA and AMPA antagonists acting by different mechanisms. The interaction with glutamatergic receptors was confirmed in the binding assay. (+)MK-801 and phencyclidine (PCP) produced similar changes in horizontal activity, i.e., a strong increase fromthe begining of the test. Ketamine, and to a lesser extent, memantine, enhanced horizontal activity at the later observation periods only. Amantadine and NBQX produced a slight inhibition, while GYKI-52466, d-cycloserine, (+R)-HA-966, CGP-37849, and dextromethorphan were ineffective. Vertical activity (rearings) were inhibited by most agents except GYKI-52466 and gly-B partial agonists. At higher doses ataxia was seen after: MK-801, PCP, ketamine, memantine, amantadine, CGP-37849, dextromethorphan, and GYKI-52466. Hence, the inhibition of NMDA and AMPA receptors by agents acting at different recognition sites produces qualitatively different behavioral consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:19:53