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Titolo:
EFFECTS OF CLONIDINE AND ALPHA-METHYL-P-TYROSINE ON THE CARBACHOL STIMULATION OF PARADOXICAL SLEEP
Autore:
MASTRANGELO D; DESAINTHILAIREKAFI Z; GAILLARD JM;
Indirizzi:
UNIV GENEVA,INST PSYCHIAT,CHEMIN PETIT-BEL-AIR 2 CH-1225 CHENE BOURG SWITZERLAND UNIV GENEVA,INST PSYCHIAT CH-1225 CHENE BOURG SWITZERLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 48, anno: 1994,
pagine: 93 - 100
SICI:
0091-3057(1994)48:1<93:EOCAAO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; ALPHA-2-ADRENERGIC AGONIST CLONIDINE; MOVING GUINEA-PIGS; BRAIN-STEM; REM-SLEEP; WAKE CYCLE; CORTICAL ACETYLCHOLINE; WAKING CYCLE; RAT-BRAIN; INHIBITION;
Keywords:
CHOLINERGIC SYSTEM; NORADRENERGIC SYSTEM; CARBACHOL; CLONIDINE; ALPHA-METHYL-PARA-TYROSINE; PARADOXICAL SLEEP; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
D. Mastrangelo et al., "EFFECTS OF CLONIDINE AND ALPHA-METHYL-P-TYROSINE ON THE CARBACHOL STIMULATION OF PARADOXICAL SLEEP", Pharmacology, biochemistry and behavior, 48(1), 1994, pp. 93-100

Abstract

Acetylcholine promotes paradoxical sleep (PS), but the role of noradrenaline in this stimulation is controversial. The relationship betweencholinergic and noradrenergic systems in the production of PS was investigated in the rat implanted on a continuous basis for sleep recordings. Stimulation of PS was obtained with microinjections of carbachol (1 mu g) into the pontine reticular formation. In the presence of the alpha(2)-agonist clonidine (5 mu g/kg, IP), the carbachol activation of PS was abolished. This stimulation also disappeared when the animalswere pretreated with alpha-methyl-paratyrosine (150 mg/kg, IP), an inhibitor of catecholamine synthesis. Thus, carbachol stimulation appeared inefficient when brain noradrenergic activation was decreased. Thisobservation supports the view that the realization of PS by the cholinergic system requires a certain level of noradrenergic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:09:16