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Titolo:
INVOLVEMENT OF DOPAMINE D-2 RECEPTOR MECHANISM IN THE REM-SLEEP DEPRIVATION-INDUCED INCREASE IN SWIMMING ACTIVITY IN THE FORCED SWIMMING TEST
Autore:
ASAKURA W; MATSUMOTO K; OHTA H; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,PHARMACOL SECT,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,PHARMACOL SECT TOYAMA 93001 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 48, anno: 1994,
pagine: 43 - 46
SICI:
0091-3057(1994)48:1<43:IODDRM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL DESPAIR; ANTI-IMMOBILITY; LIMBIC SYSTEM; DESIPRAMINE; MICE; RATS; ANTIDEPRESSANTS; ANTAGONISM; DRUGS;
Keywords:
REM SLEEP DEPRIVATION; FORCED SWIMMING TEST; DOPAMINE; ALPHA-METHYL-P-TYROSINE; SCH23390; SULPIRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W. Asakura et al., "INVOLVEMENT OF DOPAMINE D-2 RECEPTOR MECHANISM IN THE REM-SLEEP DEPRIVATION-INDUCED INCREASE IN SWIMMING ACTIVITY IN THE FORCED SWIMMING TEST", Pharmacology, biochemistry and behavior, 48(1), 1994, pp. 43-46

Abstract

Effects of monoamine synthesis inhibitors and dopamine antagonists onrapid eye movement sleep (REMs) deprivation treatment-induced increase in swimming activity were examined. Mice were deprived of REMs for 48 h by a small pedestal method. Swimming activity in REMs-deprived mice was significantly higher than those in group-housed or socially isolated animals used as the control. dl-alpha-Methyl-p-tyrosine methyl ester HCl (250 mg/kg, IP) decreased the swimming activity in REMs-deprived mice, whereas neither disulfiram (400 mg/kg, SC), a noradrenaline synthesis inhibitor, nor dl-p-chlorophenylalanine methyl ester HCl (300mg/kg, IP) changed it. (+)-SCH23390 HCl (30 and 100 mu g/kg, IP), a selective dopamine D-1 antagonist, did not affect the activity in REMs-deprived mice. (+/-)-Sulpiride (12.5 and 25 mg/kg, IP), a selective dopamine D-2 antagonist, dose-dependently decreased swimming activity inREMs-deprived mice, while it did not significantly change the swimming activity in the control animals. These results suggest that REMs deprivation treatment-induced increase in swimming activity is mainly dueto the functional changes in the dopaminergic system rather than the noradrenergic or serotonergic system, and that dopamine D-2 but not D-1 receptor mechanism is involved in the increase in swimming activity in REMs-deprived animals.

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Documento generato il 20/01/21 alle ore 02:39:26