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Titolo:
NICOTINE-INDUCED ANTINOCICEPTION IN MICE - ROLE OF G-PROTEINS AND ADENYLATE-CYCLASE
Autore:
DAMAJ MI; WELCH SP; MARTIN BR;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 48, anno: 1994,
pagine: 37 - 42
SICI:
0091-3057(1994)48:1<37:NAIM-R>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL CHROMAFFIN CELLS; RAT CENTRAL NEURONS; ACETYLCHOLINE-RECEPTOR; CALCIUM INFLUX; CATECHOLAMINE SECRETION; DOPAMINE RELEASE; FORSKOLIN; CHANNELS; BOVINE; DESENSITIZATION;
Keywords:
NICOTINE; CYCLIC AMP; ANTINOCICEPTION; G-PROTEINS; MICE; FORSKOLIN; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Damaj et al., "NICOTINE-INDUCED ANTINOCICEPTION IN MICE - ROLE OF G-PROTEINS AND ADENYLATE-CYCLASE", Pharmacology, biochemistry and behavior, 48(1), 1994, pp. 37-42

Abstract

The effects of pertussis toxin, forskolin, and cAMP analogues on the antinociceptive action of nicotine were examined to investigate the possible involvement of adenylate cyclase and G-proteins in nicotine's antinociceptive effect. Intrathecal injection of pertussis toxin (0.25 and 0.50 pg) in mice inhibited nicotine-induced antinociception in thetail-flick test. The effect of the toxin was dose and time dependent. Forskolin, a potent adenylate cyclase activator, and 8-(-4-chlorophenylthio) adenosine-3':5' monophosphate, cyclic (8-CPT-cAMP), a cAMP analogue, inhibited the antinociceptive effects of nicotine in a dose-dependent manner. EGTA reversal of 8-CPT-cAMP's inhibitory effects suggests that calcium may to be involved. These data implicate the possible involvement of a G-protein and a second messenger system (activation of a cAMP-dependent protein kinase and increase in cyclic AMP levels) in nicotine-induced analgesia in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:11:46