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Titolo:
LOCAL EXCISION OF RECTAL-CARCINOMA - EARLY RESULTS WITH COMBINED CHEMORADIATION THERAPY USING 5-FLUOROURACIL AND LEUCOVORIN
Autore:
GRAHAM RA; ATKINS MB; KARP DD; WAZER DE; HACKFORD AW;
Indirizzi:
750 WASHINGTON ST,BOX 1043 BOSTON MA 02111 TUFTS UNIV,SCH MED,DEPT SURG BOSTON MA 02111 TUFTS UNIV,SCH MED,DEPT RADIAT ONCOL BOSTON MA 02111 TUFTS UNIV,SCH MED,DIV HEMATOL ONCOL BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR BOSTON MA 00000
Titolo Testata:
Diseases of the colon & rectum
fascicolo: 4, volume: 37, anno: 1994,
pagine: 308 - 312
SICI:
0012-3706(1994)37:4<308:LEOR-E>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANAGEMENT; CANCER;
Keywords:
LOCAL EXCISION; CHEMORADIATION THERAPY; RECTAL CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Graham et al., "LOCAL EXCISION OF RECTAL-CARCINOMA - EARLY RESULTS WITH COMBINED CHEMORADIATION THERAPY USING 5-FLUOROURACIL AND LEUCOVORIN", Diseases of the colon & rectum, 37(4), 1994, pp. 308-312

Abstract

PURPOSE: This study was undertaken to evaluate the treatment morbidity, functional outcome, and recurrence risk of patients undergoing local excision and combined chemoradiation therapy for rectal carcinoma. METHODS: Eighteen patients underwent local excision of their rectal carcinoma. Four patients underwent local excision alone (T1-2, NO-X, low risk), 10 patients underwent local excision with postoperative chemoradiation therapy using 5-fluorouracil and leucovorin (T1-2, NO-X, high risk), and 4 patients underwent local excision, chemoradiation therapy, and six months of additional 5-fluorouracil and leucovorin (T3or N1). RESULTS: Of the four patients undergoing local excision alone, therewas no treatment morbidity or alteration in functional outcome. Of the 14 patients receiving chemoradiation therapy, three reported early Grade 3-4 toxicitymanifested by cystitis, proctitis, or perineal skin desquamation. At six months, two patients reported persistent rectal urgency and occasional fecal incontinence, and 11 patients reported increasing stool frequency (average, 3: range, 2-8). The six months of additional 5-fluorouracil and leucovorin were well tolerated and did not appear to further affect functional outcome. There were no local recurrences, although one patient developed distant mestastatic disease. CONCLUSION: This treatment regimen, while generally well tolerated, is associated with significant acute toxicity in certain patients. We haveidentified specific causative factors which can be modified to decrease acute morbidity, including the elimination of leucovorin during thecombined chemoradiation therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:22:11