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Titolo:
CHEMICAL DERIVATIZATION FOR ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY.1. ALKYL-HALIDES, ALCOHOLS, PHENOLS, THIOLS, AND AMINES
Autore:
QUIRKE JME; ADAMS CL; VANBERKEL GJ;
Indirizzi:
OAK RIDGE NATL LAB,DIV CHEM & ANALYT SCI OAK RIDGE TN 37831 FLORIDA INT UNIV,DEPT CHEM MIAMI FL 33199
Titolo Testata:
Analytical chemistry
fascicolo: 8, volume: 66, anno: 1994,
pagine: 1302 - 1315
SICI:
0003-2700(1994)66:8<1302:CDFEM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION TRAP; PEPPERMINT OIL; CHROMATOGRAPHY; BIOMOLECULES; CHLOROPHENOLS; DESORPTION; PEPTIDES; SPECTRA; CATIONS; ACETATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J.M.E. Quirke et al., "CHEMICAL DERIVATIZATION FOR ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY.1. ALKYL-HALIDES, ALCOHOLS, PHENOLS, THIOLS, AND AMINES", Analytical chemistry, 66(8), 1994, pp. 1302-1315

Abstract

Derivatization strategies and specific derivatization reactions for conversion of simple alkyl halides, alcohols, phenols, thiols, and amines to ionic or solution-ionizable derivatives, that is ''electrospray active'' (ES-active) forms of the analyte, are presented. Use of thesereactions allows detection of analytes among those listed that are not normally amenable to analysis by electrospray ionization mass spectrometry (ES-MS). In addition, these reactions provide for analysis specificity and flexibility through functional group specific derivatization and through the formation of derivatives that can be detected in positive ion or in negative ion mode. For a few of the functional groups, amphoteric derivatives are formed that can be analyzed in either positive or negative ion modes. General synthetic strategies for transformation of members of these five compound classes to ES-active species are presented along with illustrative examples of suitable derivatives. Selected derivatives were prepared using model compounds and the ES mass spectra obtained for these derivatives are discussed. The analytical utility of derivatization for ES-MS analysis is illustrated in three experiments: (1) specific detection of the major secondary alcohol in oil of peppermint, (2) selective detection of phenols within a synthetic mixture of phenols, and (3) identification of the medicinal amines within a commercially available cold medication as primary, secondary or tertiary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:11:18