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Titolo:
ANGIOGENESIS AS A DIAGNOSTIC FACTOR IN PRIMARY BREAST-CANCER - MICROVESSEL QUANTITATION BY STEREOLOGICAL METHODS AND CORRELATION WITH COLORDOPPLER SONOGRAPHY
Autore:
GRISCHKE EM; KAUFMANN M; EBERLEINGONSKA M; MATTFELDT T; SOHN C; BASTERT G;
Indirizzi:
UNIV HEIDELBERG,FRAUENKLIN,VOSSSTR 9 D-69115 HEIDELBERG GERMANY UNIV HEIDELBERG,INST PATHOL W-6900 HEIDELBERG GERMANY UNIV ULM,INST PATHOL W-7900 ULM GERMANY
Titolo Testata:
Onkologie
fascicolo: 1, volume: 17, anno: 1994,
pagine: 35 - 42
SICI:
0378-584X(1994)17:1<35:AAADFI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOVASCULARIZATION; METASTASIS; ULTRASOUND; CARCINOMA; MELANOMA;
Keywords:
ANGIOGENESIS; MICROVESSEL QUANTITATION; STEREOLOGY; COLOR DOPPLER SONOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Grischke et al., "ANGIOGENESIS AS A DIAGNOSTIC FACTOR IN PRIMARY BREAST-CANCER - MICROVESSEL QUANTITATION BY STEREOLOGICAL METHODS AND CORRELATION WITH COLORDOPPLER SONOGRAPHY", Onkologie, 17(1), 1994, pp. 35-42

Abstract

Background: In contrast to benign lesions without signs of inflammation, malignant tumors have a capacity for angiogenesis. Therefore it was of interest to evaluate with color Doppler ultrasound if breast carcinomas showed higher vascularization than benign lesions. To enable a correlation with the pathoanatomic situation of vascularization, stereological methods were used to quantify microvessel volume, surface andlength as indicators for angiogenesis. Patients and Methods: Two hundred and five patients with a palpable and/or mammographically seen breast tumor were investigated before they underwent surgery with color Doppler ultrasound for the detection of blood flow in the tumor or in an area around the tumor within a distance of 2 cm. In 101 cases microvessels of the tumor were identified by immunohistochemistry using the monoclonal mouse antibody (JC70) that detects the vascular endothelium-associated antigen CD31 and quantified by stereological methods. The quantified vessel volume, surface, and length were compared to color flow results and other prognostic factors in breast cancer. Results: The detection of blood flow by color Doppler sonography in the tumor andin the peritumoral region was significantly higher in malignant than in benign breast lesions (p=0.003). By stereological quantitation of microvessels it could be shown that breast carcinoma had a significantly higher volume, surface and length of vessels than fibroadenoma (p<0.00001 and p<0.0001). In the group of breast cancers a significant correlation was found between high length of microvessels per mm(3) tumor and tumor size (p=004 - Jonckheere test), a negative estrogen receptor(p<0.007) and a negative progesterone receptor (p=0.005). No correlation was found between microvessel length and nodal status, tumor grade, ploidy status, and S-phase fraction. Conclusions: Microvessel count in breast tumors, using the JC70 antibody to CD31, and stereology for quantitation in a three-dimensional fashion, is an effective method tolook for the extent of angiogenesis and to correlate Doppler flow results with pathoanatomic vascular data. With color Doppler sonography an effective clinical method is available for distinguishing between benign and malignant lesions.

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Documento generato il 15/07/20 alle ore 08:26:27