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Titolo:
CHRONIC IDIOPATHIC NEUTROPENIA ASSOCIATED WITH ABNORMAL EXPRESSION OFGRANULOCYTE-COLONY-STIMULATING FACTOR MESSENGER-RNA OF BONE-MARROW STROMAL CELLS
Autore:
KOHGO Y; HIRAYAMA Y; MATSUNAGA T; KATO J; SAKAMAKI S; NIITSU Y;
Indirizzi:
SAPPORO MED COLL,DEPT INTERNAL MED 4,SOUTH-1,WEST-16,CHUO KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
International journal of hematology
fascicolo: 3, volume: 59, anno: 1994,
pagine: 177 - 180
SICI:
0925-5710(1994)59:3<177:CINAWA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Keywords:
CHRONIC IDIOPATHIC NEUTROPENIA; STROMAL CELL; G-CSF; MESSENGER RNA; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kohgo et al., "CHRONIC IDIOPATHIC NEUTROPENIA ASSOCIATED WITH ABNORMAL EXPRESSION OFGRANULOCYTE-COLONY-STIMULATING FACTOR MESSENGER-RNA OF BONE-MARROW STROMAL CELLS", International journal of hematology, 59(3), 1994, pp. 177-180

Abstract

Chronic idiopathic neutropenia is an uncommon condition characterizedby a low level of neutrophils without any causative disease. We report the details of 4 patients whose stromal cytokine mRNA expressions were examined by reverse transcription polymerase chain reaction. Three patients showed a lower expression of granulocyte colony-stimulating factor (G-CSF) mRNA both in constructive and lipopolysaccharide (LPS)-induced conditions and normal colony forming unit-granulocyte-macrophage (CFU-GM) from the bone marrow cells. One patient showed an increase of G-CSF mRNA and a decrease of CFU-GM. No abnormal expression of other cytokines including interleukin (IL)-1beta, IL-6 and IL-8 were observed. These findings indicate that cytokine mRNA analysis of stromal cells is useful for elucidation of the etiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:34:41