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Titolo:
THE INTERACTION BETWEEN PRENATAL STRESS AND NEONATAL HANDLING ON NOCICEPTIVE RESPONSE LATENCIES IN MALE AND FEMALE RATS
Autore:
SMYTHE JW; MCCORMICK CM; ROCHFORD J; MEANEY MJ;
Indirizzi:
MCGILL UNIV,DOUGLAS HOSP,RES CTR,DEPT PSYCHIAT,DEV NEURENDOCRINOL LAB,6875 LASALLE BLVD MONTREAL H4H 1R3 PQ CANADA BATES COLL,DEPT PSYCHOL LEWISTON ME 04240
Titolo Testata:
Physiology & behavior
fascicolo: 5, volume: 55, anno: 1994,
pagine: 971 - 974
SICI:
0031-9384(1994)55:5<971:TIBPSA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BINDING; INDUCED BEHAVIOR; ADULT-RATS; BRAIN; SENSITIVITY; THRESHOLD; MORPHINE; PAIN;
Keywords:
PAW LICK; NEONATAL; HANDLING; PRENATAL; STRESS; SEX DIFFERENCES; NOCICEPTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Smythe et al., "THE INTERACTION BETWEEN PRENATAL STRESS AND NEONATAL HANDLING ON NOCICEPTIVE RESPONSE LATENCIES IN MALE AND FEMALE RATS", Physiology & behavior, 55(5), 1994, pp. 971-974

Abstract

Neonatal handling produces physiological and behavioral changes that persist into adulthood. These effects are opposite to those resulting from prenatal stress (PS). We examined the interaction between PS and handling on nociception in adult male and female rats. Randomly selected pregnant rats were subjected to restraint stress on days 13-17 of gestation for 25 min each day, or left undisturbed. At birth, selected stressed/nonstressed litters were assigned to be handled. Handling consisted of 15 min of separation from the dam, once per day, from postnatal days 1-14. At 4 months of age, rats were placed on a 50 degrees C hot plate, and their latencies to paw lick were recorded. Prenatal stress and handling interacted to affect latencies in male rats. Handled (H)/PS rats had significantly lower paw lick latencies than nonhandled(NH)/PS rats (p < 0.05). However, handling had no effect on the male offspring of control dams. Handling elevated paw lick latencies in thefemale offspring of control dams, an effect that was most pronounced in diestrous vs. estrous rats. The NH/PS rats showed significantly elevated latencies compared to NH/NS rats (p < 0.05). These results suggest that handling effects on nociception are most apparent in rats subjected to PS; in males at least, these effects would otherwise not be present.

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Documento generato il 05/07/20 alle ore 07:08:31