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Titolo:
EFFECTS OF MONOAMINE-OXIDASE INHIBITORS AND DOPAMINE AGONISTS ON THE BEHAVIOR OF MAMMAL-EATING AND FROG-EATING SNAKES
Autore:
TEMPLE JG; BARTHALMUS GT;
Indirizzi:
N CAROLINA STATE UNIV,DEPT ZOOL RALEIGH NC 27695
Titolo Testata:
Physiology & behavior
fascicolo: 5, volume: 55, anno: 1994,
pagine: 927 - 933
SICI:
0031-9384(1994)55:5<927:EOMIAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; SINOAORTIC-DENERVATED RATS; XENOPUS SKIN MUCUS; HEMORRHAGIC-SHOCK; TARDIVE-DYSKINESIA; DEPRENYL; PATHOPHYSIOLOGY; MODULATION; MECHANISM; MOVEMENTS;
Keywords:
MAO-A; MAO-B; MONOAMINE OXIDASE; DOPAMINE AGONISTS; DEPRENYL; CLORGYLINE; SNAKES; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Temple e G.T. Barthalmus, "EFFECTS OF MONOAMINE-OXIDASE INHIBITORS AND DOPAMINE AGONISTS ON THE BEHAVIOR OF MAMMAL-EATING AND FROG-EATING SNAKES", Physiology & behavior, 55(5), 1994, pp. 927-933

Abstract

Skin mucus of the frog, Xenopus laevis, induces climbing and attenuates tongue flicking in Nerodia sipedon; these effects are induced aloneand are potentiated by L-deprenyl, a monoamine oxidase type B inhibitor (MAO-B-i), but not by clorgyline, an MAO type A inhibitor (MAO-A(i)). Both MAO-A and MAO-B metabolize dopamine, with MAO-B having the higher affinity; MAO-A selectively metabolizes serotonin and norepinephrine and MAO-B is selective for phenylethylamine. It was hypothesized that clorgyline and L-deprenyl would differentially modulate tongue flicking and climbing in frog-eating (Nerodia erythrogaster) and mammaphagous (Elaphe o. obsoleta) snakes, based on physiological differences between the species. L-Deprenyl caused a decrease in tongue flicking andclimbing by Elaphe and an increase in climbing by Nerodia, whereas clorgyline did not alter tongue flicking, climbing, or locomotor activity in either species. To further assess the role of dopamine, hybrid black/gray rat snakes, E. o. spiloides, were administered the D-1 and D-2 dopamine receptor agonists SKF 77434 (SKF 38393, N-allyl) and quinpirole, respectively. SKF 77434 and quinpirole attenuated climbing, but only SKF 77434 attenuated tongue flicking in Experiment 3; neither drug affected locomotor activity. Results suggest that dopaminergic stimulation by MAO-B-i and dopamine agonists modulates tongue flicking and climbing behaviors in snakes, and that the contrasting climbing reactions induced by MAO-B-i between Elaphe and Nerodia may be linked to quantitative differences in endogenous catecholamine levels and/or to thenumbers and sensitivity of receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:23:07