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Titolo:
DEMENTIA PRECEDING MOTOR SYMPTOMS IN PARKINSONS-DISEASE - A CASE-STUDY
Autore:
HEDERA P; COHEN ML; LERNER AJ; FRIEDLAND RP;
Indirizzi:
UNIV HOSP CLEVELAND,CTR ALZHEIMER,DEPT NEUROL,2074 ABINGTON RD CLEVELAND OH 44106 UNIV HOSP CLEVELAND,CTR ALZHEIMER,DEPT NEUROL,2074 ABINGTON RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DIV NEUROPATHOL CLEVELAND OH 44106
Titolo Testata:
Neuropsychiatry, neuropsychology, and behavioral neurology
fascicolo: 1, volume: 7, anno: 1994,
pagine: 67 - 72
SICI:
0894-878X(1994)7:1<67:DPMSIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEWY BODY DISEASE; NEUROPATHOLOGICAL FINDINGS; PROGRESSIVE DEMENTIA; ALZHEIMERS-DISEASE; CLINICAL-DIAGNOSIS; IMMUNOCYTOCHEMISTRY; DEGENERATION; EXPRESSION; UBIQUITIN; ACCURACY;
Keywords:
PARKINSONS DISEASE; DEMENTIA; LEWY BODIES; DIFFUSE LEWY BODY DISEASE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P. Hedera et al., "DEMENTIA PRECEDING MOTOR SYMPTOMS IN PARKINSONS-DISEASE - A CASE-STUDY", Neuropsychiatry, neuropsychology, and behavioral neurology, 7(1), 1994, pp. 67-72

Abstract

A 57-year-old man developed signs of cognitive decline followed, 2 years later, by mild extrapyramidal symptoms. Neuropathologic examination demonstrated Lewy bodies almost exclusively confined to the substantia nigra and brainstem nuclei (consistent with idiopathic Parkinson's disease [PD] alone) with the superimposition of dystrophic neurites inareas CA2-3 of the hippocampus immunostained with antibodies to ubiquitin. This case study demonstrates that dementia may be a presenting symptom of PD and supports a continuity between PD and diffuse Lewy body disease.

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Documento generato il 24/11/20 alle ore 14:20:26