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Titolo:
CYST FLUID CYTOLOGIC ANALYSIS IN THE DIFFERENTIAL-DIAGNOSIS OF PANCREATIC CYSTIC LESIONS
Autore:
CENTENO BA; LEWANDROWSKI KB; WARSHAW AL; COMPTON CC; SOUTHERN JF;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PATHOL,55 FRUIT ST BOSTON MA 02114 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PATHOL BOSTON MA 02114 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT SURG BOSTON MA 02114
Titolo Testata:
American journal of clinical pathology
fascicolo: 4, volume: 101, anno: 1994,
pagine: 483 - 487
SICI:
0002-9173(1994)101:4<483:CFCAIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINE-NEEDLE ASPIRATION; MUCINOUS CYSTADENOCARCINOMA; CARCINOEMBRYONIC ANTIGEN; NEOPLASMS; TUMORS;
Keywords:
CYST; CYSTADENOCARCINOMA; CYTOLOGY; FINE-NEEDLE ASPIRATION; MUCINOUS CYSTIC NEOPLASM; PANCREAS, PAPILLARY CYSTADENOCARCINOMA; PSEUDOCYST; SEROUS CYSTADENOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Centeno et al., "CYST FLUID CYTOLOGIC ANALYSIS IN THE DIFFERENTIAL-DIAGNOSIS OF PANCREATIC CYSTIC LESIONS", American journal of clinical pathology, 101(4), 1994, pp. 483-487

Abstract

Pancreatic cystic lesions include inflammatory pseudocysts, benign serous cystadenomas, and mucinous neoplasms, some of which are malignant. Cytologic analysis of cyst fluid has been proposed to diagnose pancreatic cysts before definitive therapy. The authors report an analysis of 31 pancreatic cyst aspirates: 9 pseudocysts, 5 serous cystadenomas,8 mucinous cystic neoplasms, 4 mucinous cystadenocarcinomas, 2 papillary cystadenocarcinomas, 1 mucinous ductal adenocarcinoma with cystic degeneration, and 2 cystic islet cell tumors. All pseudocysts were correctly classified as probable inflammatory lesions, because of the presence of abundant acute inflammation and histiocytes and the absence of glandular epithelium. Three of five serous cystadenomas were correctly classified, based on the presence of small cuboidal cells in clusters with microvesicular cytoplasm containing glycogen. Eleven of 12 mucinous tumors contained round cells with large cytoplasmic mucin vacuoles or columnar cells containing cytoplasmic mucin. Malignancy was diagnosed in 5 of 7 carcinomas, 1 case was classified as suspicious for malignancy, and 1 case was nondiagnostic because of the absence of a cellular component. The authors concluded that pancreatic cyst fluid cytologic analysis is useful in differentiating mucinous from nonmucinous pancreatic cysts and may provide definitive evidence of malignancy. Insome cases, serous cystadenoma can be diagnosed based on cytologic analysis. An inflammatory smear without epithelial cells suggests a pseudocyst, but these findings are nonspecific, as a similar pattern may occur when a cystic neoplasm undergoes degenerative changes. Therefore,pseudocyst remains a diagnosis of exclusion.

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Documento generato il 26/11/20 alle ore 14:26:42