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Titolo:
POWER SPECTRAL-ANALYSIS OF ELECTROENCEPHALOGRAPHIC DESYNCHRONIZATION INDUCED BY COCAINE IN THE RAT
Autore:
CHANG AYW; KUO TBJ; CHAN SHH;
Indirizzi:
NATL YANG MING MED COLL,INST PHARMACOL TAIPEI 11221 TAIWAN NATL YANG MING MED COLL,INST PHARMACOL TAIPEI 11221 TAIWAN
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 170, anno: 1994,
pagine: 175 - 178
SICI:
0304-3940(1994)170:1<175:PSOEDI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EEG; DOPAMINE;
Keywords:
COCAINE; POWER SPECTRAL ANALYSIS; ELECTROENCEPHALOGRAM; DESYNCHRONIZATION; ROOT MEAN SQUARE; MEAN POWER FREQUENCY; EEG SPECTRAL COMPONENT; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
A.Y.W. Chang et al., "POWER SPECTRAL-ANALYSIS OF ELECTROENCEPHALOGRAPHIC DESYNCHRONIZATION INDUCED BY COCAINE IN THE RAT", Neuroscience letters, 170(1), 1994, pp. 175-178

Abstract

Whereas it is well-known that cocaine induces EEG desynchronization and behavioral excitation in animals and human subjects, the detailed effect of cocaine on EEG activity remains to be fully elucidated. This communication reports our attempts in quantifying the effect of cocaine on EEG signals recorded from the somatosensory cortex of adult male Sprague-Dawley rats under chloral hydrate anesthesia (400 mg/kg i.p.). Continuous, on-line and real-time power spectral analysis revealed that i.v. administration of two doses of cocaine (1.5 or 3.0 mg/kg) dose-dependently induced EEG desynchronization, as indicated by a decreasein the root mean square and an increase in the mean power frequency values. More interestingly, whereas both doses of cocaine promoted a reduction in the alpha (8-13 Hz), Theta (4-8 Hz) and delta (1-4 Hz) spectral components, the beta band (13-32 Hz) underwent differential alterations. The lower dose of cocaine elicited a transient increase, followed by a decrease in the power of the beta band. A prolonged increase in the power of the beta band, on the other hand, was observed after the higher dose of cocaine. These results suggest that subtle changes in the individual EEG spectral components, which are dose-dependent, may underlie the EEG desynchronization induced by cocaine.

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Documento generato il 04/07/20 alle ore 20:29:38