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Titolo:
DEFECTS ON SPECT PERFUSION IMAGES CAN OCCUR DUE TO ABNORMAL SEGMENTALCONTRACTION
Autore:
EISNER RL; SCHMARKEY LS; MARTIN SE; CAREY D; WORTHY MA; CHU TH; HOROWITZ SF; PATTERSON RE;
Indirizzi:
EMORY CRAWFORD LONG HOSP,CARLYLE FRASER HEART CTR,DEPT NUCL CARDIOL,550 PEACHTREE ST NE ATLANTA GA 30365 EMORY UNIV,SCH MED,DEPT RADIOL ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT MED CARDIOL ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT PHYSIOL ATLANTA GA 30322 CUNY MT SINAI SCH MED,BETH ISRAEL MED CTR,DEPT MED CARDIOL NEW YORK NY 00000
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 4, volume: 35, anno: 1994,
pagine: 638 - 643
SICI:
0161-5505(1994)35:4<638:DOSPIC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; MYOCARDIAL PERFUSION; TC-99M SESTAMIBI; WALL MOTION; TL-201; QUANTITATION; THICKNESS; KINETICS; ISCHEMIA; DOGS;
Keywords:
SPECT MYOCARDIAL PERFUSION IMAGING; GATED SPECT; TECHNETIUM-99M-SESTAMIBI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Eisner et al., "DEFECTS ON SPECT PERFUSION IMAGES CAN OCCUR DUE TO ABNORMAL SEGMENTALCONTRACTION", The Journal of nuclear medicine, 35(4), 1994, pp. 638-643

Abstract

Technetium-99m-sestamibi images reflect tracer distribution at the time of injection. This ''stay put'' indicator allowed us to separate the effects of segmental left ventricular dysfunction per se versus myocardial blood flow on SPECT ''perfusion'' images in ten dogs. Methods: An electromagnetic flow probe and hydraulic occluder were placed on the LAD coronary artery. Sonomicrometry was used to measure segmental wall shortening. At peak myocardial blood flow induced by adenosine, 35-45 mCi Tc-99m-sestamibi were injected without occlusion. A 1 hr postinjection, during normal contraction, 40-50 msec end-diastolic and end-systolic SPECT images (#1) were acquired to reflect normal myocardial blood flow distribution. Later, during total LAD occlusion, and withoutreinjection of isotope, another gated scan (#2) was acquired. Results: Coincident with abnormal contraction, large severe systolic;defects [(28 +/- 5)% more severe compared to the baseline-scan #1; p < 0.01], and milder diastolic defects [(12 +/- 8)% more severe compared to the baseline-scan #1; p < 0.01] were observed during scan #2. Thus, abnormal contraction alone produced defects on SPECT images. Conclusion: Accordingly, defects in myocardial perfusion images must be interpreted as representing the integrated result of the combination of blood flow and segmental contraction heterogeneity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 12:34:24