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Titolo:
THE ORGANIZATION OF MIDBRAIN PROJECTIONS TO THE STRIATUM IN THE PRIMATE - SENSORIMOTOR-RELATED STRIATUM VERSUS VENTRAL STRIATUM
Autore:
LYNDBALTA E; HABER SN;
Indirizzi:
UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROBIOL & ANAT,601 ELMWOOD AVE ROCHESTER NY 14642 UNIV ROCHESTER,SCH MED & DENT,DEPT NEUROBIOL & ANAT ROCHESTER NY 14642
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 59, anno: 1994,
pagine: 625 - 640
SICI:
0306-4522(1994)59:3<625:TOOMPT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS ACCUMBENS SEPTI; MONKEY SAIMIRI-SCIUREUS; RHESUS-MONKEY; SUBSTANTIA NIGRA; BRAIN-STEM; CATECHOLAMINERGIC NEURONS; HORSERADISH-PEROXIDASE; MONOAMINE DISTRIBUTION; EFFERENT CONNECTIONS; CORTICAL AFFERENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
E. Lyndbalta e S.N. Haber, "THE ORGANIZATION OF MIDBRAIN PROJECTIONS TO THE STRIATUM IN THE PRIMATE - SENSORIMOTOR-RELATED STRIATUM VERSUS VENTRAL STRIATUM", Neuroscience, 59(3), 1994, pp. 625-640

Abstract

In order to examine the organization of nigrostriatal projections in the primate, the retrograde tracers Lucifer Yellow conjugated to dextran amines and horseradish peroxidase conjugated to wheatgerm agglutinin were injected into different regions of the dorsolateral and ventralstriatum. Based on the topography of cortical inputs to the striatum,the dorsalateral striatum is associated with the motor system, and the ventral striatum is related to the limbic system. Our results indicate that although midbrain neurons projecting to the ventral and dorsolateral striatum are mostly separate, there are neurons projecting to these different striatal territories that overlap in the medial substantia nigra. The dopaminergic neurons of the ventral mesencephalon can be subdivided into dorsal and Ventral tiers that include the cells of the ventral tegmental area, the substantia nigra pars compacta, and theretrorubral area. Neurons projecting to the ventral striatum are found in both the dorsal and ventral tiers. A large number of neurons occupying the medial densocellular zone of the ventral tier are labeled following injections into different regions of the ventral striatum. Neuron Neurons projecting to the sensorimotor-related striatum are derived almost exclusively from the ventral tier. Many of these neurons are located very ventrally in the substantia nigra, where clusters of neurons invade the pars reticulata. In addition, labeled neurons are foundthroughout the mediolateral extent of the densocellular zone of the pars compacta. Notably, neurons are labeled in the medial densocellularzone following injections into the dorsolateral and ventral striatum. Mesencephalic neurons projecting to different striatal territories are distinct in that dorsal tier neurons mainly innervate the ventral striatum, whereas the ventral columns of neurons in the ventral tier innervate the sensorimotor-related striatum. Thus, the dopaminergic regulation of the sensorimotor-related striatum and the ventral striatum may be different. However, a subgroup of dopaminergic neurons in the medial densocellular zone projects to both striatal territories. Such divergent projections may allow the substantia nigra to serve as a link, connecting different striatal territories, via their connections with the substantia nigra.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:54:15