Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CLINICAL AND HISTOLOGIC INVOLVEMENT OF REGIONAL LYMPH-NODES IN MALIGNANT-MELANOMA - ADJUVANT VINDESINE IMPROVES SURVIVAL
Autore:
RETSAS S; QUIGLEY M; PECTASIDES D; MACRAE K; HENRY K;
Indirizzi:
CHARING CROSS HOSP,DEPT MED ONCOL,FULHAM PALACE RD LONDON W6 8RF ENGLAND WESTMINSTER MED SCH & HOSP,MED ONCOL UNIT LONDON ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT MED STAT LONDON ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT HISTOPATHOL LONDON ENGLAND
Titolo Testata:
Cancer
fascicolo: 8, volume: 73, anno: 1994,
pagine: 2119 - 2130
SICI:
0008-543X(1994)73:8<2119:CAHIOR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC FACTORS; COMBINATION THERAPY; CUTANEOUS MELANOMA; ONCOLOGY-GROUP; SINGLE AGENT; DISSECTION; METASTASES; CHEMOTHERAPY; CANCER; TRIAL;
Keywords:
MELANOMA; MALIGNANT; METASTATIC; LYMPH NODES; CHEMOTHERAPY; ADJUVANT; VINDESINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S. Retsas et al., "CLINICAL AND HISTOLOGIC INVOLVEMENT OF REGIONAL LYMPH-NODES IN MALIGNANT-MELANOMA - ADJUVANT VINDESINE IMPROVES SURVIVAL", Cancer, 73(8), 1994, pp. 2119-2130

Abstract

Background. This report is a study of prognostic factors, including adjuvant chemotherapy, that influence survival of patients with malignant melanoma who have clinical and pathologic involvement of regional lymph nodes. Methods. A total of 169 evaluable patients with malignant melanoma metastatic to regional lymph nodes were registered consecutively and prospectively between Tune 1977 and December 1986 in the computerized data base of the melanoma registry at Westminster Hospital. Eighty-seven of these patients received adjuvant chemotherapy with vindesine after resection of palpable metastatic lymph nodes, and 82 had nosystemic treatment after surgery. All were followed up for at least 2years (median, 8 years) after involvement of regional lymph nodes wasnoted or until death. Statistical analyses included simple life-tablecomparisons, unadjusted for covariates. In addition, Breslow's thickness, ulceration of the primary lesion, its anatomical location, numberof regional lymph nodes histologically involved, dissection site, patient age and sex, and adjuvant vindesine therapy were included as covariates in Cox regression models. Results. The disease-free interval (P= 0.0001), time to dissemination from lymph node metastases (P < 0.0001), survival time after lymph node dissection (P = 0.0227) and overall survival time after initial diagnosis of malignant melanoma (P = 0.0095, log-rank chi-square test) were superior for the 87 patients who received adjuvant chemotherapy with vindesine. Cox regression analysis confirmed adjuvant vindesine as a highly significant variable influencing all of these outcomes, including overall survival time after firstdiagnosis (P = 0.003). Conclusions. The apparent effect of adjuvant vindesine on overall survival in this study is large (hazard ratio, 0.52) and highly statistically significant. Adjuvant vindesine therapy merits consideration for malignant melanoma metastatic to regional lymphnodes. However, these results observed in concurrent, but nonrandomized, patients clearly require confirmation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:29:20